• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

水解产物通过减轻氧化应激、炎症和细胞凋亡对顺铂诱导的肾毒性的改善作用。

Ameliorative Effect of Hydrolysate on Cisplatin-Induced Nephrotoxicity by Mitigating Oxidative Stress, Inflammation and Apoptosis.

作者信息

Tao Susu, Qi Yi, Gao Jialong, Yuan Huafang, Wang Ruimin, Shen Xiaoqin, Wei Gang, Peng Zhilan

机构信息

School of Ocean and Tropical Medicine, Guangdong Medical University, Zhanjiang 524023, China.

College of Food Science & Technology, Guangdong Provincial Key Laboratory of Aquatic Products Processing and Safety, Zhanjiang 524088, China.

出版信息

Mar Drugs. 2025 Feb 24;23(3):100. doi: 10.3390/md23030100.

DOI:10.3390/md23030100
PMID:40137286
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11943811/
Abstract

The present study investigated the protective effects and possible mechanisms of an ultrafiltration fraction of hydrolysate (UFSH) on cisplatin-induced kidney damage in a mouse model. The results showed that UFSH significantly attenuated cisplatin-induced nephrotoxicity by inhibiting increases in blood urea nitrogen (BUN) and serum creatinine (SCr). Additionally, UFSH treatment significantly alleviated cisplatin-induced renal histopathological changes, such as significant dilation of renal tubules, cast formation, and tubular cell necrosis, as well as tubulointerstitial fibrosis. Moreover, UFSH decreased cisplatin-induced oxidative stress by increasing the activities of antioxidant enzymes SOD and GSH-Px, while reducing the malondialdehyde (MDA) level in the kidney. Furthermore, UFSH significantly inhibited cisplatin-induced increases in inflammatory cytokines, including Interleukin 1-beta (IL-1β), Interleukin-6 (IL-6), and Tumor necrosis factor-alpha (TNF-α). Western blotting revealed that UFSH inhibited the phosphorylation of the inflammation-associated MAPK/NF-κB signaling pathway, lowered the expression of the apoptosis-related protein Bax, and reversed the reduction in the anti-apoptotic Bcl-2 protein. This investigation demonstrated that UFSH can ameliorate cisplatin-induced nephrotoxicity by mitigating oxidative stress, inflammation, and apoptosis.

摘要

本研究在小鼠模型中探究了水解产物超滤组分（UFSH）对顺铂诱导的肾损伤的保护作用及可能机制。结果显示，UFSH通过抑制血尿素氮（BUN）和血清肌酐（SCr）升高，显著减轻了顺铂诱导的肾毒性。此外，UFSH治疗显著减轻了顺铂诱导的肾脏组织病理学变化，如肾小管显著扩张、管型形成、肾小管细胞坏死以及肾小管间质纤维化。而且，UFSH通过提高抗氧化酶超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性，同时降低肾脏中丙二醛（MDA）水平，减少了顺铂诱导的氧化应激。此外，UFSH显著抑制了顺铂诱导的炎性细胞因子升高，包括白细胞介素1-β（IL-1β）、白细胞介素-6（IL-6）和肿瘤坏死因子-α（TNF-α）。蛋白质免疫印迹法显示，UFSH抑制了炎症相关的丝裂原活化蛋白激酶/核因子-κB（MAPK/NF-κB）信号通路的磷酸化，降低了凋亡相关蛋白Bax的表达，并逆转了抗凋亡蛋白Bcl-2的减少。本研究表明，UFSH可通过减轻氧化应激、炎症和凋亡来改善顺铂诱导的肾毒性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/3e87fb38d473/marinedrugs-23-00100-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/bf8f55cb13b4/marinedrugs-23-00100-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/8cd641ab1582/marinedrugs-23-00100-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/1ecc5b6e48ea/marinedrugs-23-00100-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/60aba713b088/marinedrugs-23-00100-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/7c909ead62af/marinedrugs-23-00100-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/7b5569f89a46/marinedrugs-23-00100-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/66ff263565f7/marinedrugs-23-00100-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/82716ecfcab2/marinedrugs-23-00100-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/fea72d446a9c/marinedrugs-23-00100-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/29c590fc7808/marinedrugs-23-00100-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/3e87fb38d473/marinedrugs-23-00100-g011.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/bf8f55cb13b4/marinedrugs-23-00100-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/8cd641ab1582/marinedrugs-23-00100-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/1ecc5b6e48ea/marinedrugs-23-00100-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/60aba713b088/marinedrugs-23-00100-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/7c909ead62af/marinedrugs-23-00100-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/7b5569f89a46/marinedrugs-23-00100-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/66ff263565f7/marinedrugs-23-00100-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/82716ecfcab2/marinedrugs-23-00100-g008.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/fea72d446a9c/marinedrugs-23-00100-g009.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/29c590fc7808/marinedrugs-23-00100-g010.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/3290/11943811/3e87fb38d473/marinedrugs-23-00100-g011.jpg

相似文献

1
Ameliorative Effect of Hydrolysate on Cisplatin-Induced Nephrotoxicity by Mitigating Oxidative Stress, Inflammation and Apoptosis.水解产物通过减轻氧化应激、炎症和细胞凋亡对顺铂诱导的肾毒性的改善作用。
Mar Drugs. 2025 Feb 24;23(3):100. doi: 10.3390/md23030100.
2
Ginsenoside Rg5 Ameliorates Cisplatin-Induced Nephrotoxicity in Mice through Inhibition of Inflammation, Oxidative Stress, and Apoptosis.人参皂苷Rg5通过抑制炎症、氧化应激和细胞凋亡改善顺铂诱导的小鼠肾毒性。
Nutrients. 2016 Sep 13;8(9):566. doi: 10.3390/nu8090566.
3
Sinapic acid modulates Nrf2/HO-1 signaling pathway in cisplatin-induced nephrotoxicity in rats.芥子酸调节顺铂诱导的大鼠肾毒性中的Nrf2/HO-1信号通路。
Biomed Pharmacother. 2017 Sep;93:646-653. doi: 10.1016/j.biopha.2017.06.085. Epub 2017 Jul 4.
4
Theaflavin alleviates cisplatin-induced nephrotoxicity: Targeting SIRT1/p53/FOXO3a/Nrf2 signaling and the NF-kB inflammatory cascade.茶黄素减轻顺铂诱导的肾毒性：靶向沉默信息调节因子1/ p53/叉头框蛋白O3a/核因子E2相关因子2信号通路和核因子κB炎症级联反应。
Food Chem Toxicol. 2025 Apr;198:115334. doi: 10.1016/j.fct.2025.115334. Epub 2025 Feb 19.
5
Galangin ameliorates cisplatin-induced nephrotoxicity by attenuating oxidative stress, inflammation and cell death in mice through inhibition of ERK and NF-kappaB signaling.高良姜通过抑制ERK和NF-κB信号传导，减轻氧化应激、炎症和细胞死亡，从而改善顺铂诱导的小鼠肾毒性。
Toxicol Appl Pharmacol. 2017 Aug 15;329:128-139. doi: 10.1016/j.taap.2017.05.034. Epub 2017 May 27.
6
Supplementation of American ginseng berry extract mitigated cisplatin-evoked nephrotoxicity by suppressing ROS-mediated activation of MAPK and NF-κB signaling pathways.补充西洋参浆果提取物通过抑制ROS介导的MAPK和NF-κB信号通路激活减轻顺铂诱发的肾毒性。
Food Chem Toxicol. 2017 Dec;110:62-73. doi: 10.1016/j.fct.2017.10.006. Epub 2017 Oct 10.
7
Genipin attenuates cisplatin-induced nephrotoxicity by counteracting oxidative stress, inflammation, and apoptosis.金皮苷通过拮抗氧化应激、炎症和细胞凋亡来减轻顺铂诱导的肾毒性。
Biomed Pharmacother. 2017 Sep;93:1083-1097. doi: 10.1016/j.biopha.2017.07.018. Epub 2017 Jul 20.
8
Embelin attenuates cisplatin-induced nephrotoxicity: Involving inhibition of oxidative stress and inflammation in addition with activation of Nrf-2/Ho-1 pathway.恩贝林减轻顺铂诱导的肾毒性：涉及抑制氧化应激和炎症，以及激活 Nrf-2/Ho-1 通路。
Biofactors. 2019 May;45(3):471-478. doi: 10.1002/biof.1502. Epub 2019 Mar 20.
9
Mitigation of ILβ-1, ILβ-6, TNF-α, and markers of apoptosis by ursolic acid against cisplatin-induced oxidative stress and nephrotoxicity in rats.熊果酸对顺铂诱导的大鼠氧化应激和肾毒性中 ILβ-1、ILβ-6、TNF-α 和细胞凋亡标志物的抑制作用。
Hum Exp Toxicol. 2021 Dec;40(12_suppl):S397-S405. doi: 10.1177/09603271211045953. Epub 2021 Sep 26.
10
Vindoline mitigates cisplatin-mediated kidney damage by alleviating redox imbalance, apoptosis and inflammation through extracellular signal-regulated kinase pathway modulation.长春多灵通过细胞外信号调节激酶途径调控减轻氧化还原失衡、细胞凋亡和炎症，从而减轻顺铂介导的肾损伤。
J Physiol Pharmacol. 2024 Dec;75(6). doi: 10.26402/jpp.2024.6.06. Epub 2025 Feb 3.

本文引用的文献

1
Relationship between magnesium dosage and the preventive effect on cisplatin-induced nephrotoxicity: meta-analysis and meta-regression analysis.镁剂量与顺铂诱导的肾毒性预防效果之间的关系：荟萃分析和荟萃回归分析。
Int J Clin Oncol. 2024 Dec;29(12):1817-1824. doi: 10.1007/s10147-024-02629-6. Epub 2024 Sep 24.
2
Biomarkers in acute kidney injury.急性肾损伤中的生物标志物
Ann Intensive Care. 2024 Sep 15;14(1):145. doi: 10.1186/s13613-024-01360-9.
3
Urea to creatinine ratio as a predictor of persistent critical illness.尿素氮与肌酐比值对持续危重症的预测作用。
J Crit Care. 2024 Oct;83:154834. doi: 10.1016/j.jcrc.2024.154834. Epub 2024 May 22.
4
Oxidative stress and the role of redox signalling in chronic kidney disease.氧化应激与氧化还原信号在慢性肾脏病中的作用。
Nat Rev Nephrol. 2024 Feb;20(2):101-119. doi: 10.1038/s41581-023-00775-0. Epub 2023 Oct 19.
5
Purification and Identification of Peptides from Oyster () Protein Enzymatic Hydrolysates and Their Anti-Skin Photoaging Effects on UVB-Irradiated HaCaT Cells.牡蛎（）蛋白酶解产物中肽的分离鉴定及其对 UVB 照射 HaCaT 细胞的抗皮肤光老化作用。
Mar Drugs. 2022 Nov 28;20(12):749. doi: 10.3390/md20120749.
6
Ojeoksan Ameliorates Cisplatin-Induced Acute Kidney Injury in Mice by Downregulating MAPK and NF-κB Pathways.莪术醇通过下调 MAPK 和 NF-κB 通路减轻顺铂诱导的小鼠急性肾损伤。
Int J Mol Sci. 2022 Oct 14;23(20):12254. doi: 10.3390/ijms232012254.
7
MicroRNAs Involved in Intrinsic Apoptotic Pathway during Cisplatin-Induced Nephrotoxicity: Potential Use of Natural Products against DDP-Induced Apoptosis.顺铂诱导肾毒性过程中涉及的内在凋亡途径的 microRNAs：天然产物对 DDP 诱导的细胞凋亡的潜在应用。
Biomolecules. 2022 Aug 31;12(9):1206. doi: 10.3390/biom12091206.
8
Renoprotective Effect of GKA4 on Cisplatin-Induced Acute Kidney Injury by Mitigating Inflammation and Oxidative Stress and Regulating the MAPK, AMPK/SIRT1/NF-κB, and PI3K/AKT Pathways.GKA4 通过减轻炎症和氧化应激以及调节 MAPK、AMPK/SIRT1/NF-κB 和 PI3K/AKT 通路对顺铂诱导的急性肾损伤的肾保护作用。
Nutrients. 2022 Jul 13;14(14):2877. doi: 10.3390/nu14142877.
9
Fish Collagen Peptides Protect against Cisplatin-Induced Cytotoxicity and Oxidative Injury by Inhibiting MAPK Signaling Pathways in Mouse Thymic Epithelial Cells.鱼胶原蛋白肽通过抑制 MAPK 信号通路保护小鼠胸腺上皮细胞免受顺铂诱导的细胞毒性和氧化损伤。
Mar Drugs. 2022 Mar 28;20(4):232. doi: 10.3390/md20040232.
10
Novel polysaccharide extracted from Sipunculus nudus inhibits HepG2 tumour growth in vivo by enhancing immune function and inducing tumour cell apoptosis.从星虫中提取的新型多糖通过增强免疫功能和诱导肿瘤细胞凋亡来抑制体内 HepG2 肿瘤的生长。
J Cell Mol Med. 2021 Sep;25(17):8338-8351. doi: 10.1111/jcmm.16793. Epub 2021 Jul 24.