Wikland M, Lindblom B, Wiqvist N
Acta Physiol Hung. 1985;65(3):331-4.
The contractile response of small myometrial specimens from the term pregnant human uterus was investigated using a superfusion technique. Adrenaline, noradrenaline and dopamine all had a stimulatory effect on the contractility. It was also demonstrated that this stimulatory effect was alpha-adrenoceptor mediated. If the tissue was pretreated with the prostaglandin synthetase inhibitor indomethacin or the arachidonic acid analogue eicosa-5,8,11,14-tetraenoic acid the effect of catecholamines was significantly reduced. This suggests a specific role of prostaglandins in the mechanism of action of catecholamines on the human myometrium.
采用灌流技术研究了足月妊娠人子宫小子宫肌层标本的收缩反应。肾上腺素、去甲肾上腺素和多巴胺均对收缩性有刺激作用。还证明这种刺激作用是由α-肾上腺素能受体介导的。如果用前列腺素合成酶抑制剂吲哚美辛或花生四烯酸类似物5,8,11,14-二十碳四烯酸对组织进行预处理，儿茶酚胺的作用会显著降低。这表明前列腺素在儿茶酚胺对人子宫肌层的作用机制中具有特定作用。
