Uesaki Shoko, Yamato Masanori, Ishikado Atsushi, Suekawa Yutaka, Tamura Yasuhisa, Kataoka Yosky
R&D Department, Sunstar Inc., 3-1 Asahimachi, Takatsuki 569-1195, Osaka, Japan.
Laboratory for Cellular Function Imaging, RIKEN Center for Biosystems Dynamics Research, 6-7-3 Minatojima-minamimachi, Chuo-ku, Kobe 650-0047, Hyogo, Japan.
NeuroSci. 2025 Mar 1;6(1):19. doi: 10.3390/neurosci6010019.
Insufficient sleep and circadian misalignment increase inflammatory agents. This triggers neuroinflammation and can result in health issues including depression, dementia, lifestyle-related diseases, and industrial accidents. Lactoferrin (LF) confers neuroprotective effects, which are derived from its anti-inflammatory, antioxidant, and iron metabolic properties; however, its roles in acute neuroinflammation and circadian rhythm disruption are yet to be elucidated. Therefore, we aimed to test the effects of LF on rat neuroinflammation and sleep and jetlag in humans. Rats received 7 days of an oral liposomal bovine LF (L-bLF) or vehicle followed by polyriboinosinic:polyribocytidylic acid (poly I:C) peritoneal injections (n = 5-6). Compared with the rats given poly I:C only, the rats given L-bLF and poly I:C had lower Il1b, Tnf, Casp1, Nfe212, Gclm, and Sod2 expression in the hippocampus. This open-label pilot study was carried out on tour conductors performing regular international tour responsibilities, and the data were compared between the initial tour without L-bLF intake and the subsequent tour with L-bLF intake. In the tour with L-bLF intake, L-bLF administration started from one week before the trip and was continued during the trip. In both periods, the tour conductors experienced limited sleep; however, both subjective and objective sleep quality was significantly better with the oral L-bLF intake than without. Overall, we found that prophylactic L-bLF supplementation reduced neuroinflammation in rat hippocampi and improved sleep quality and jetlag in tour conductors.
睡眠不足和昼夜节律失调会增加炎症介质。这会引发神经炎症，并可能导致包括抑郁症、痴呆症、生活方式相关疾病和工业事故在内的健康问题。乳铁蛋白（LF）具有神经保护作用，这源于其抗炎、抗氧化和铁代谢特性；然而，其在急性神经炎症和昼夜节律紊乱中的作用尚待阐明。因此，我们旨在测试LF对大鼠神经炎症以及对人类睡眠和时差反应的影响。大鼠连续7天口服脂质体牛乳铁蛋白（L-bLF）或赋形剂，随后腹腔注射聚肌苷酸：聚胞苷酸（poly I:C）（n = 5 - 6）。与仅给予poly I:C的大鼠相比，给予L-bLF和poly I:C的大鼠海马体中Il1b、Tnf、Casp1、Nfe212、Gclm和Sod2的表达较低。这项开放标签的试点研究是针对定期承担国际巡演职责的导游进行的，数据在未摄入L-bLF的首次巡演和随后摄入L-bLF的巡演之间进行比较。在摄入L-bLF的巡演中，L-bLF给药从旅行前一周开始，并在旅行期间持续。在两个时期，导游的睡眠都有限；然而，口服L-bLF时，主观和客观睡眠质量均显著优于未服用时。总体而言，我们发现预防性补充L-bLF可减轻大鼠海马体中的神经炎症，并改善导游的睡眠质量和时差反应。
