Eghbalifard Negar, Nouri Nikta, Rouzbahani Shiva, Bakhshi Maryam, Ghasemi Kahrizsangi Negin, Golafshan Faraz, Abbasi Fatemeh
School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Islamic Azad University of Najaf Abad, Affiliated Hospitals, Isfahan, Iran.
Discov Oncol. 2025 Mar 26;16(1):399. doi: 10.1007/s12672-025-02150-w.
The potential implications of Coronavirus disease-2019 (COVID-19) on oral squamous cell carcinoma (OSCC) development, chemo-resistance, tumor recurrence, and patient outcomes are explored, emphasizing the urgent need for tailored therapeutic strategies to mitigate these risks. The role of hypoxia-inducible factor 1-alpha (HIF-1α) in OSCC studies has highlighted HIF-1α as a crucial prognostic marker in OSCC, with implications for disease prognosis and patient survival. Its overexpression has been linked to aggressive subtypes in early OSCC stages, indicating its significance as an early biomarker for disease progression. Moreover, dysplastic lesions with heightened HIF-1α expression exhibit a greater propensity for malignant transformation, underscoring its role in early oral carcinogenesis. Cancer patients, including those with OSCC, face an elevated risk of severe COVID-19 complications, which may further impact cancer progression and treatment outcomes. Understanding the interplay between COVID-19 infection, HIF-1α activation, and OSCC pathogenesis is crucial for enhancing clinical management strategies. So, insights from this review shed light on the significance of HIF-1α in OSCC tumorigenesis, metastasis formation, and patient prognosis. The review underscores the need for further research to elucidate the precise mechanisms through which HIF-1α modulates cancer progression and chemo-resistance in the context of COVID-19 infection. Such knowledge is essential for developing targeted therapeutic interventions to improve outcomes for OSCC patients.
本文探讨了2019冠状病毒病（COVID-19）对口腔鳞状细胞癌（OSCC）发生、化疗耐药、肿瘤复发及患者预后的潜在影响，强调迫切需要制定针对性的治疗策略以降低这些风险。缺氧诱导因子1α（HIF-1α）在OSCC研究中的作用已突显其为OSCC的关键预后标志物，对疾病预后和患者生存具有重要意义。其过表达与早期OSCC阶段的侵袭性亚型相关，表明其作为疾病进展早期生物标志物的重要性。此外，HIF-1α表达升高的发育异常病变具有更高的恶性转化倾向，突出了其在早期口腔癌发生中的作用。包括OSCC患者在内的癌症患者面临发生严重COVID-19并发症的更高风险，这可能进一步影响癌症进展和治疗结果。了解COVID-19感染、HIF-1α激活与OSCC发病机制之间的相互作用对于加强临床管理策略至关重要。因此，本综述的见解揭示了HIF-1α在OSCC肿瘤发生、转移形成及患者预后中的重要性。该综述强调需要进一步研究以阐明在COVID-19感染背景下HIF-1α调节癌症进展和化疗耐药的确切机制。此类知识对于开发靶向治疗干预措施以改善OSCC患者的治疗结果至关重要。
