Sheng Denghai, Guo Shuaihang, Li Aiqing, Wu Qiulian, Zhan Mengying, Liu Xiaoli, Chen Hong
State and Local Joint Engineering Laboratory for Novel Functional Polymeric Materials, College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China.
Biomacromolecules. 2025 Apr 14;26(4):2540-2552. doi: 10.1021/acs.biomac.5c00016. Epub 2025 Mar 26.
Nitric oxide (NO), known for its anticoagulant and antiproliferative effects, holds great promise in anticoagulation therapy. Copper-based metal-organic frameworks, such as CuBTTri, catalyze NO formation, but their impact on vascular cells requires further study. In this work, polydopamine, polyethylenimine, and CuBTTri were codeposited on titanium substrates. To enhance cytocompatibility, heparin-mimicking copolymers were incorporated. By adjusting CuBTTri content, NO release rates and cytotoxicity toward vascular cells were regulated. The heparin-mimicking copolymers improved the cytocompatibility with human umbilical vein endothelial cells, while NO released from CuBTTri inhibited the proliferation of human umbilical vein smooth muscle cells. By integrating NO-releasing CuBTTri with heparin-mimicking copolymers, we successfully developed a composite coating that selectively modulates vascular cell behavior.
一氧化氮（NO）以其抗凝和抗增殖作用而闻名，在抗凝治疗中具有巨大潜力。铜基金属有机框架，如CuBTTri，可催化NO的形成，但其对血管细胞的影响尚需进一步研究。在这项工作中，聚多巴胺、聚乙烯亚胺和CuBTTri共沉积在钛基底上。为提高细胞相容性，引入了肝素模拟共聚物。通过调整CuBTTri的含量，调节了NO释放速率和对血管细胞的细胞毒性。肝素模拟共聚物改善了与人脐静脉内皮细胞的细胞相容性，而CuBTTri释放的NO抑制了人脐静脉平滑肌细胞的增殖。通过将释放NO的CuBTTri与肝素模拟共聚物相结合，我们成功开发了一种能够选择性调节血管细胞行为的复合涂层。
