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DIFENSE Study Protocol: Early Intervention With Difamilast Ointment in Infantile Early-Onset Atopic Dermatitis for Prevention of Transcutaneous Sensitisation.

作者信息

Yamamoto-Hanada Kiwako, Okamoto Kazuyoshi, Kishimoto Nobuharu, Tsuchiya Kunihiko, Natsume Osamu, Takemura Yutaka, Narita Masami, Kobayashi Tohru, Ohya Yukihiro

机构信息

Allergy Center, National Center for Child Health and Development, Tokyo, Japan.

Otsuka Pharmaceutical Co., Ltd., Tokyo, Japan.

出版信息

Clin Exp Allergy. 2025 Jul;55(7):580-582. doi: 10.1111/cea.70039. Epub 2025 Mar 26.

DOI:10.1111/cea.70039
PMID:40139221
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12221857/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e5c/12221857/6139f4735999/CEA-55-580-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e5c/12221857/6139f4735999/CEA-55-580-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/2e5c/12221857/6139f4735999/CEA-55-580-g001.jpg

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本文引用的文献

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Does Appropriate Timing for Early Introduction Differ Between Hen's Eggs and Nuts?
Clin Exp Allergy. 2024 Sep;54(9):700-702. doi: 10.1111/cea.14519. Epub 2024 Jul 28.
2
Management of Infant Atopic Eczema to Prevent Severe Eczema and Food Allergy.婴儿特应性皮炎的管理以预防严重特应性皮炎和食物过敏。
Clin Exp Allergy. 2024 Sep;54(9):669-681. doi: 10.1111/cea.14515. Epub 2024 Jun 12.
3
Enhanced early skin treatment for atopic dermatitis in infants reduces food allergy.婴儿特应性皮炎的强化早期皮肤治疗可降低食物过敏风险。
J Allergy Clin Immunol. 2023 Jul;152(1):126-135. doi: 10.1016/j.jaci.2023.03.008. Epub 2023 Mar 22.
4
Difamilast, a selective phosphodiesterase 4 inhibitor, ointment in paediatric patients with atopic dermatitis: a phase III randomized double-blind, vehicle-controlled trial.地氟米特，一种选择性磷酸二酯酶 4 抑制剂，治疗特应性皮炎患儿的软膏：一项 III 期随机双盲、安慰剂对照试验。
Br J Dermatol. 2022 Jan;186(1):40-49. doi: 10.1111/bjd.20655. Epub 2021 Nov 1.
5
Skincare interventions in infants for preventing eczema and food allergy: A cochrane systematic review and individual participant data meta-analysis.婴幼儿护肤品干预预防特应性皮炎和食物过敏的效果：一项 Cochrane 系统评价和个体参与者数据荟萃分析。
Clin Exp Allergy. 2021 Mar;51(3):402-418. doi: 10.1111/cea.13847. Epub 2021 Feb 25.
6
Earlier aggressive treatment to shorten the duration of eczema in infants resulted in fewer food allergies at 2 years of age.早期积极治疗以缩短婴儿湿疹病程，可降低其2岁时食物过敏的发生率。
J Allergy Clin Immunol Pract. 2020 May;8(5):1721-1724.e6. doi: 10.1016/j.jaip.2019.11.036. Epub 2019 Dec 9.
7
Use of Tape Strips to Detect Immune and Barrier Abnormalities in the Skin of Children With Early-Onset Atopic Dermatitis.使用胶带条检测早发性特应性皮炎儿童皮肤的免疫和屏障异常。
JAMA Dermatol. 2019 Dec 1;155(12):1358-1370. doi: 10.1001/jamadermatol.2019.2983.
8
Study of the Atopic March: Development of Atopic Comorbidities.特应性进程研究：特应性共病的发展
Pediatr Dermatol. 2016 Jul;33(4):388-98. doi: 10.1111/pde.12867. Epub 2016 Jun 7.
9
Which infants with eczema are at risk of food allergy? Results from a population-based cohort.哪些患有湿疹的婴儿有食物过敏风险？基于人群队列研究的结果。
Clin Exp Allergy. 2015 Jan;45(1):255-64. doi: 10.1111/cea.12406.