植物驯化中的顺式调控动态

Cis-regulatory dynamics in plant domestication.

作者信息

Li Xiang, Schmitz Robert J

机构信息

Department of Genetics, University of Georgia, Athens, GA 30602, USA.

出版信息

Trends Genet. 2025 Mar 25. doi: 10.1016/j.tig.2025.02.005.

DOI:10.1016/j.tig.2025.02.005

PMID:40140332

Abstract

Cis-regulatory elements (CREs) are critical sequence determinants for spatiotemporal control of gene expression. Genetic variants within CREs have driven phenotypic transitions from wild to cultivated plants during domestication. This review summarizes our current understanding of genetic variants within CREs involved in plant domestication. We also propose avenues for studies to expand our understanding of both CRE biology and domestication processes, such as examining primary mechanisms that generate CRE genetic variants during plant domestication and investigating the roles of CREs in domestication syndrome. Additionally, we discuss existing challenges and highlight future opportunities for exploring CREs in plant domestication, emphasizing the potential of modifying CREs to contribute to crop improvement.

摘要

顺式作用元件（CREs）是基因表达时空控制的关键序列决定因素。在驯化过程中，CREs内的遗传变异推动了从野生植物到栽培植物的表型转变。本综述总结了我们目前对参与植物驯化的CREs内遗传变异的理解。我们还提出了一些研究途径，以扩大我们对CRE生物学和驯化过程的理解，例如研究植物驯化过程中产生CRE遗传变异的主要机制，以及探究CREs在驯化综合征中的作用。此外，我们讨论了现有挑战，并强调了在植物驯化中探索CREs的未来机遇，着重指出了修饰CREs对作物改良的潜力。