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海马体通路中诱发反应的动力学由警觉状态的持续时间编码。

Dynamics of evoked responses in hippocampal pathways are encoded by the duration of vigilance states.

作者信息

Marchal Paul, Salin Paul A, Missaire Mégane, Rampon Manon, Carponcy Julien, Parmentier Régis, Poe Gina, Malleret Gaël, Comte Jean-Christophe

机构信息

University Claude Bernard Lyon 1, Forgetting processes and cortical dynamics' team, Centre de Recherche en Neurosciences de Lyon, Bron, France.

Department of Integrative Biology and Physiology, University of California Los Angeles, Los Angeles, CA, USA.

出版信息

Nat Commun. 2025 Mar 26;16(1):2973. doi: 10.1038/s41467-025-57976-3.

DOI:10.1038/s41467-025-57976-3
PMID:40140369
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11947198/
Abstract

Interactions among brain areas are essential to most cognitive functions. Neuronal interactions between these areas depend on the modulation of synaptic strength. However, this modulation remains poorly understood. We recorded evoked responses at four hippocampal pathways in freely moving male rats across 24 hours. We show that synaptic strength at these pathways oscillates with a very slow periodicity and correlates with the durations of vigilance states. A model based on hypnogram data and synaptic strength at one pathway was able to predict the evolution of synaptic strength at most pathways, except one. These results reveal that the temporal succession of vigilance states may contribute to memory processes through rapid modulation of synaptic strength at several pathways during the sleep-wakefulness cycle, suggesting that memory processes are not only dependent on sleep amount but also on sleep architecture.

摘要

脑区之间的相互作用对大多数认知功能至关重要。这些区域之间的神经元相互作用依赖于突触强度的调节。然而，这种调节仍知之甚少。我们在自由活动的雄性大鼠中记录了24小时内四个海马通路的诱发反应。我们发现这些通路的突触强度以非常缓慢的周期振荡，并与警觉状态的持续时间相关。基于一个通路的睡眠图数据和突触强度建立的模型能够预测除一个通路外的大多数通路突触强度的变化。这些结果表明，警觉状态的时间序列可能通过在睡眠-觉醒周期中对多个通路的突触强度进行快速调节来促进记忆过程，这表明记忆过程不仅依赖于睡眠量，还依赖于睡眠结构。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/4088b1b71f41/41467_2025_57976_Fig9_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/f40684efd20f/41467_2025_57976_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/4088b1b71f41/41467_2025_57976_Fig9_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/6c27ff2f5a3d/41467_2025_57976_Fig1_HTML.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/81bf8f8cfbaf/41467_2025_57976_Fig4_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/c5b40334d10c/41467_2025_57976_Fig5_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/17657fb713f0/41467_2025_57976_Fig6_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/63742b0de971/41467_2025_57976_Fig7_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/f40684efd20f/41467_2025_57976_Fig8_HTML.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/91e0/11947198/4088b1b71f41/41467_2025_57976_Fig9_HTML.jpg

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本文引用的文献

1
Synapse-Specific Modulation of Synaptic Responses by Brain States in Hippocampal Pathways.脑状态对海马通路突触反应的突触特异性调制。
J Neurosci. 2023 Feb 15;43(7):1191-1210. doi: 10.1523/JNEUROSCI.0772-22.2022. Epub 2023 Jan 11.
2
Stability of neocortical synapses across sleep and wake states during the critical period in rats.大鼠关键期睡眠和觉醒状态下新皮层突触的稳定性。
Elife. 2021 Jun 21;10:e66304. doi: 10.7554/eLife.66304.
3
Working and Reference Memory Tasks Trigger Opposed Long-Term Synaptic Changes in the Rat Dentate Gyrus.
工作记忆和参考记忆任务在大鼠齿状回引发相反的长期突触变化。
Cereb Cortex. 2021 May 10;31(6):2980-2992. doi: 10.1093/cercor/bhaa405.
4
Neuromodulation of Brain State and Behavior.脑状态和行为的神经调节。
Annu Rev Neurosci. 2020 Jul 8;43:391-415. doi: 10.1146/annurev-neuro-100219-105424. Epub 2020 Apr 6.
5
Daily Oscillation of the Excitation-Inhibition Balance in Visual Cortical Circuits.视皮层回路中兴奋-抑制平衡的日常波动。
Neuron. 2020 Feb 19;105(4):621-629.e4. doi: 10.1016/j.neuron.2019.11.011. Epub 2019 Dec 9.
6
Primed to Sleep: The Dynamics of Synaptic Plasticity Across Brain States.准备入睡：跨脑状态的突触可塑性动态变化
Front Syst Neurosci. 2019 Feb 1;13:2. doi: 10.3389/fnsys.2019.00002. eCollection 2019.
7
The Cortical States of Wakefulness.清醒的皮质状态。
Front Syst Neurosci. 2019 Jan 8;12:64. doi: 10.3389/fnsys.2018.00064. eCollection 2018.
8
Hippocampal theta power pressure builds over non-REM sleep and dissipates within REM sleep episodes.海马体θ波功率压力在非快速眼动睡眠期间逐渐增强，并在快速眼动睡眠阶段消散。
Arch Ital Biol. 2018 Sep 1;156(3):112-126. doi: 10.12871/00039829201833.
9
Highly Dynamic Spatiotemporal Organization of Low-Frequency Activities During Behavioral States in the Mouse Cerebral Cortex.在小鼠大脑皮层的行为状态下，低频活动的高度动态时空组织。
Cereb Cortex. 2017 Dec 1;27(12):5444-5462. doi: 10.1093/cercor/bhw311.
10
Network Homeostasis and State Dynamics of Neocortical Sleep.新皮质睡眠的网络稳态与状态动态
Neuron. 2016 May 18;90(4):839-52. doi: 10.1016/j.neuron.2016.03.036. Epub 2016 Apr 28.