Kanoh T, Fujii H
Am J Clin Pathol. 1985 Jul;84(1):121-4. doi: 10.1093/ajcp/84.1.121.
The authors have reviewed 17 cases of the phagocytic multiple myeloma, including seven cases reported in Japan but not cited in the English literature and an additional new case investigated in the authors' laboratory. They would like to add these Japanese cases to the English literature. The salient features of these 17 cases were summarized to have a better understanding of the clinical aspects as well as of the pathogenesis of the phagocytic myeloma cells. The following two clinical points should be noted: The erythrophagocytosis by myeloma cells may be responsible for the hemolytic anemia in multiple myeloma. Myeloma cells were found in the peripheral blood in more cases of this series than expected. The pathogenesis of this phenomenon, related to the cellular origin of plasma cells, may be interpreted differently, as discussed in this report.
作者回顾了17例噬血细胞性多发性骨髓瘤病例，其中包括7例日本报道但未被英文文献引用的病例以及作者实验室研究的1例新增病例。他们希望将这些日本病例补充到英文文献中。总结这17例病例的显著特征，以便更好地了解噬血细胞性骨髓瘤的临床特点及发病机制。应注意以下两个临床要点：骨髓瘤细胞的红细胞吞噬作用可能是多发性骨髓瘤患者发生溶血性贫血的原因。本系列病例中，外周血中发现骨髓瘤细胞的情况比预期更为常见。正如本报告中所讨论的，与浆细胞的细胞起源相关的这一现象的发病机制可能有不同的解释。
