Balcom R J, Clark D A, Rokahr J, Guancial R, Rathbun S
Am J Dis Child. 1985 Jul;139(7):701-4. doi: 10.1001/archpedi.1985.02140090063030.
Neutropenia commonly occurs in neonates with necrotizing enterocolitis (NEC). In an attempt to determine the etiology of this neutropenia, we observed the peripheral and peritoneal neutrophil cell responses of seven infants at the time of surgery. Six of seven patients had diminished peripheral neutrophil counts within 24 hours prior to surgery, with substantial mobilization of mature neutrophils into the peritoneum. We also looked at the rat peritoneum as a model for neutrophilic cell consumption using casein and Vibrio cholerae enterotoxin to cause neutrophil mobilization. With both agents, significant mobilization of neutrophils into the peritoneum occurred. Bone marrow stores in the animals were substantially decreased, but neutropenia was not observed. We speculate that the neutropenia of NEC is largely a consequence of neutrophil mobilization into the peritoneum, perhaps initiated by dietary protein and/or bacterial toxin.
中性粒细胞减少症常见于患有坏死性小肠结肠炎（NEC）的新生儿。为了确定这种中性粒细胞减少症的病因，我们观察了7名婴儿在手术时外周血和腹腔内中性粒细胞的反应。7名患者中有6名在手术前24小时内外周血中性粒细胞计数减少，同时有大量成熟中性粒细胞向腹腔内游走。我们还将大鼠腹腔作为中性粒细胞消耗的模型，使用酪蛋白和霍乱弧菌肠毒素诱导中性粒细胞游走。使用这两种物质时，均出现了中性粒细胞向腹腔内的显著游走。动物的骨髓储备显著减少，但未观察到中性粒细胞减少症。我们推测，NEC的中性粒细胞减少症在很大程度上是中性粒细胞向腹腔内游走的结果，可能是由膳食蛋白质和/或细菌毒素引发的。
