对王等人的评论。丝聚蛋白A在阿尔茨海默病中的异常受体相互作用的模拟丝聚蛋白A逆转。2023年，，13927。 （注：原文中部分内容格式不太清晰准确，翻译可能会稍显生硬，但已尽量忠实原文）
Comment on Wang et al. Simufilam Reverses Aberrant Receptor Interactions of Filamin A in Alzheimer's Disease. 2023, , 13927.
作者信息
Fluegge Keith, Fluegge Kyle
机构信息
Institute of Health and Environmental Research, Columbus, OH 43216, USA.
出版信息
Int J Mol Sci. 2025 Mar 11;26(6):2480. doi: 10.3390/ijms26062480.
Abstract
The authors have published their findings that simufilam, a small novel molecule suggested for clinical use in Alzheimer's disease (AD), restores a deleterious conformation of filamin A (FLNA), which is a large intracellular scaffolding protein, as indicated by changes in isoelectric focusing points [...].
摘要
作者发表了他们的研究结果，即simufilam（一种被建议用于阿尔茨海默病（AD）临床治疗的新型小分子）可恢复细丝蛋白A（FLNA）的有害构象，FLNA是一种大型细胞内支架蛋白，等电聚焦点的变化表明了这一点[...]。
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