de Assis Gilmara Gomes, de Sousa Maria Bernardete Cordeiro, Murawska-Ciałowicz Eugenia
Escola Superior Desporto e Lazer, Instituto Politécnico de Viana do Castelo, Rua Escola Industrial e Comercial de Nun'Álvares, 4900-347 Viana do Castelo, Portugal.
Sport Physical Activity and Health Research & Innovation Center, 4900-347 Viana do Castelo, Portugal.
Int J Mol Sci. 2025 Mar 12;26(6):2532. doi: 10.3390/ijms26062532.
Sex steroids and the neurotrophin brain-derived neurotrophic factor (BDNF) participate in neural tissue formation, phenotypic differentiation, and neuroplasticity. These processes are essential for the health and maintenance of the central nervous system.
The aim of our review is to elucidate the interaction mechanisms between BDNF and sex steroids in neuronal function.
A series of searches were performed using Mesh terms for androgen/receptors, estrogen/receptors, and BDNF/receptors, and a collection of the scientific data available on PubMed up to February 2025 about mechanical interactions between BDNF and sex steroids was included in this literature review.
This review discussed the influence of sex steroids on the formation and/or maintenance of neural circuits via different mechanisms, including the regulation of expression and signaling. Estrogens exert a time- and region-specific effect on BDNF synthesis. The nuclear estrogen receptor can directly regulate expression, independently of the presence of estrogen, in neuronal cells, whereas progesterone and testosterone upregulate expression via their specific nuclear receptors. In addition, testosterone has a positive effect on BDNF release by glial cells, which lack androgen receptors.
性类固醇和神经营养因子脑源性神经营养因子（BDNF）参与神经组织形成、表型分化和神经可塑性。这些过程对于中枢神经系统的健康和维持至关重要。
我们综述的目的是阐明BDNF与性类固醇在神经元功能中的相互作用机制。
使用关于雄激素/受体、雌激素/受体和BDNF/受体的医学主题词进行了一系列检索，并将截至2025年2月在PubMed上可获得的有关BDNF与性类固醇之间机械相互作用的科学数据收集纳入本综述。
本综述讨论了性类固醇通过不同机制对神经回路形成和/或维持的影响，包括对表达和信号传导的调节。雌激素对BDNF合成具有时间和区域特异性影响。核雌激素受体可在神经元细胞中独立于雌激素的存在直接调节表达，而孕酮和睾酮通过其特定的核受体上调表达。此外，睾酮对缺乏雄激素受体的胶质细胞释放BDNF具有积极作用。
