Rossini Fabio, Moser Tobias, Unterhofer Michael, Khalil Michael, Demjaha Rina, Tafrali Cansu, Martinez-Serrat Maria, Kuhle Jens, Leppert David, Benkert Pascal, Pfaff Johannes A R, Trinka Eugen, Pikija Slaven
Department of Neurology, Neurocritical Care and Neurorehabilitation, Christian Doppler University Hospital, Paracelsus Medical University and Center for Cognitive Neuroscience, European Reference Network EpiCARE, 5020 Salzburg, Austria.
Department of Neurology, Medical University of Graz, Auenbruggerplatz 22, 8036 Graz, Austria.
Int J Mol Sci. 2025 Mar 14;26(6):2629. doi: 10.3390/ijms26062629.
We aimed to determine whether transient global amnesia (TGA) is associated with alterations in central nervous system (CNS) injury biomarkers-serum neurofilament light chain (sNfL) and serum glial fibrillary acidic protein (sGFAP). In a prospective cohort of TGA patients, blood samples were obtained within 24-48 h of TGA onset (t0) and 6 weeks thereafter (t1). We assessed sNfL and sGFAP levels using the highly sensitive single-molecule array assay and calculated Z-scores adjusted for age, gender, and body mass index (BMI). Demographics, electroencephalography (EEG), and cerebral magnetic resonance imaging (cMRI) findings were also collected. A total of 20 patients were included (median age: 66 years, 70% women). No significant changes in sNfL or sGFAP levels associated with TGA at t0 and t1 were observed. Median sNfL Z-scores were 0.45 (interquartile range [IQR] -0.09, 1.19) at t0 and 0.60 (IQR -0.61, 1.19) at t1. Median sGFAP Z-scores were 0.27 (IQR -0.45, 0.76) at t0 and 0.44 (IQR -0.27, 0.75) at t1. Similarly, in the subgroup of patients with diffusion-weighted imaging (DWI)-positive hippocampal lesions ( = 5/20[25%]), no elevations in blood biomarkers were detected. Our pilot study on neurological blood biomarkers supports the benign nature of TGA, indicating that no CNS tissue damage occurs.
我们旨在确定短暂性全面性遗忘症（TGA）是否与中枢神经系统（CNS）损伤生物标志物——血清神经丝轻链（sNfL）和血清胶质纤维酸性蛋白（sGFAP）的变化有关。在一个TGA患者的前瞻性队列中，于TGA发作后24 - 48小时（t0）及此后6周（t1）采集血样。我们使用高灵敏度单分子阵列分析法评估sNfL和sGFAP水平，并计算根据年龄、性别和体重指数（BMI）调整后的Z分数。还收集了人口统计学数据、脑电图（EEG）和脑磁共振成像（cMRI）结果。共纳入20例患者（中位年龄：66岁，70%为女性）。未观察到t0和t1时与TGA相关的sNfL或sGFAP水平有显著变化。t0时sNfL Z分数中位数为0.45（四分位间距[IQR] -0.09，1.19），t1时为0.60（IQR -0.61，1.19）。t0时sGFAP Z分数中位数为0.27（IQR -0.45，0.76），t1时为0.44（IQR -0.27，0.75）。同样，在扩散加权成像（DWI）阳性海马病变患者亚组中（ = 5/20[25%]），未检测到血液生物标志物升高。我们关于神经血液生物标志物的初步研究支持了TGA的良性性质，表明未发生中枢神经系统组织损伤。
