Park Ye-Rin, Park So-Mi, Kim Nanyeong, Jung Jihoon, Kim Seokwoo, Kim Kwan-Il, Jang Hyeung-Jin
College of Korean Medicine, Kyung Hee University, 26, Kyungheedae-ro, Dongdaemun-gu, Seoul 02447, Republic of Korea.
Department of Science in Korean Medicine, Graduate School, Kyung Hee University, Seoul 02447, Republic of Korea.
Molecules. 2025 Mar 9;30(6):1227. doi: 10.3390/molecules30061227.
RNA-binding motif 22 (RBM22) is an RNA-binding protein involved in gene regulation, with the capacity to bind DNA and function as a transcription factor for various target genes. Recent studies demonstrated that RBM22 depletion affects cell viability and proliferation of glioblastoma and breast cancer cells. However, the role of RBM22 in colon cancer and the molecular mechanisms underlying its tumor-suppressive function remain largely unclear. In this study, we demonstrate that RBM22 induces apoptosis and suppresses colon cancer cell viability and proliferation by modulating c-Myc expression. Furthermore, RBM22 knockdown reduces c-Myc stability. Therefore, our findings suggest that RBM22 depletion regulates cancer cell proliferation and induces apoptosis via the c-Myc pathway.
RNA结合基序22（RBM22）是一种参与基因调控的RNA结合蛋白，具有结合DNA的能力，并作为各种靶基因的转录因子发挥作用。最近的研究表明，RBM22缺失会影响胶质母细胞瘤和乳腺癌细胞的细胞活力和增殖。然而，RBM22在结肠癌中的作用及其肿瘤抑制功能的分子机制仍不清楚。在本研究中，我们证明RBM22通过调节c-Myc表达诱导细胞凋亡并抑制结肠癌细胞的活力和增殖。此外，RBM22敲低降低了c-Myc的稳定性。因此，我们的研究结果表明，RBM22缺失通过c-Myc途径调节癌细胞增殖并诱导细胞凋亡。
