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揭开无声威胁:罗马尼亚布加勒斯特多发性硬化症患者心血管危险因素的患病率

Unmasking the Silent Threat: Prevalence of Cardiovascular Risk Factors in MS Patients in Bucharest, Romania.

作者信息

Pleșa Florentina Cristina, Arsene Elena Andreea, Pleșa Andreea, Bucurică Săndica, Anghel Daniela, Sîrbu Carmen Adella, Țânțu Monica Marilena, Badea Alexandru Andrei, Vasiliu Octavian, Munteanu Alice Elena

机构信息

Clinical Neurosciences Department, 'Carol Davila' University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Department of Cardiology, University Emergency Hospital Bucharest, 050098 Bucharest, Romania.

出版信息

J Clin Med. 2025 Mar 15;14(6):2001. doi: 10.3390/jcm14062001.

Abstract

This study aims to identify cardiovascular risk factors among 91 patients with multiple sclerosis in Bucharest, Romania, using data from medical records and a self-administered questionnaire. The research focuses on smoking status, body mass index, blood sugar, cholesterol, triglycerides, blood pressure, and renal function. The average age of the patients was 42.90 ± 10.60 years, and 74.73% were female. The average BMI was 23.89 kg/m ± 4.74 kg/m (lower than in the general population), with 41.76% of patients having a BMI outside normal limits. The majority were former smokers (35.87%), followed by non-smokers (28.26%), and the fewest were smokers of more than 20 cigarettes/day (7.61%). The average total cholesterol was 198.48 ± 38.56 mg/dL, triglycerides were 114.22 mg/dL ± 76.2281 mg/dL, and blood glucose was 97.54 ± 36.58 mg/dL. While 25.27% of the patients had fasting blood glucose > 126 mg/dL, only five patients were diagnosed with DM. The average blood pressure was 137.5165 ± 19.5047 mmHg, with only 11 patients diagnosed with HTA. The study found an average cardiovascular risk of 6.6133% ± 7.1412%, with higher values among males, rural patients, those with secondary-progressive MS, and those with a disease progression >10 years (after age adjustment). The study underscores the importance of identifying and combating cardiovascular risk factors in patients with multiple sclerosis.

摘要

本研究旨在利用病历数据和一份自行填写的问卷,确定罗马尼亚布加勒斯特91例多发性硬化症患者的心血管危险因素。该研究聚焦于吸烟状况、体重指数、血糖、胆固醇、甘油三酯、血压和肾功能。患者的平均年龄为42.90±10.60岁,74.73%为女性。平均体重指数为23.89kg/m±4.74kg/m(低于一般人群),41.76%的患者体重指数超出正常范围。大多数人是既往吸烟者(35.87%),其次是非吸烟者(28.26%),每天吸烟超过20支的人最少(7.61%)。平均总胆固醇为198.48±38.56mg/dL,甘油三酯为114.22mg/dL±76.2281mg/dL,血糖为97.54±36.58mg/dL。虽然25.27%的患者空腹血糖>126mg/dL,但只有5例患者被诊断为糖尿病。平均血压为137.5165±19.5047mmHg,只有11例患者被诊断为高血压。研究发现平均心血管风险为6.6133%±7.1412%,在男性、农村患者、继发进展型多发性硬化症患者以及疾病进展超过10年的患者(年龄调整后)中风险值更高。该研究强调了识别和对抗多发性硬化症患者心血管危险因素的重要性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7948/11942990/047f22c0f5db/jcm-14-02001-g002.jpg

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