Georghiou Georgios P, Xanthopoulos Andrew, Kanellopoulos George, Georghiou Panos, Georgiou Amalia, Skoularigis John, Giamouzis Grigorios, Lampropoulos Konstantinos, Patrikios Ioannis, Triposkiadis Filippos
Department of Cardiothoracic Surgery, Aretaeio Hospital, 2414 Nicosia, Cyprus.
Medical School, European University Cyprus, 2404 Nicosia, Cyprus.
J Clin Med. 2025 Mar 20;14(6):2117. doi: 10.3390/jcm14062117.
Postoperative atrial fibrillation (POAF) occurs frequently after cardiac surgery and is associated with increased morbidity and mortality. The pathogenesis of POAF in this setting is complex and not completely understood. Since cancer is a well-known risk factor for AF, the aim of this study was to identify potential predictors, including cancer, of POAF after cardiac surgery. : This prospective study included 400 consecutive patients in sinus rhythm who underwent elective cardiac surgery in Aretaeio Hospital (Nicosia, Cyprus) from January 2020 till January 2023. The primary outcome was the development of POAF during hospitalization, defined as any documented AF episode lasting >30 s. Predictors of the primary outcome were studied using univariable and multivariable logistic regression analysis. : Of the 400 patients (68 [61-73] years, 64 [16%] females) studied, 66 (16.5%) developed POAF. Among the variables examined, the only predictors of POAF were cardiopulmonary bypass time (odds ratio [OR] = 1.001, 95% confidence interval = [95% CI, 1.000-1.001], = -0.031) and cancer (OR = 3.852, 95% CI = [1.535-9.664], = 0.004). Cancer was present in 13 (4%) and in 10 (15%) of patients without and with POAF, respectively ( < 0.001). : Cancer was associated with a dramatic increase in POAF risk early after elective cardiac surgery in this study. Whether patients developing POAF after cardiac surgery should be searched for cancer deserves further investigation.
术后房颤（POAF）在心脏手术后频繁发生，且与发病率和死亡率增加相关。这种情况下POAF的发病机制复杂，尚未完全明确。由于癌症是房颤的一个众所周知的危险因素，本研究的目的是确定心脏手术后POAF的潜在预测因素，包括癌症。：这项前瞻性研究纳入了2020年1月至2023年1月在阿雷泰奥医院（塞浦路斯尼科西亚）接受择期心脏手术的400例连续窦性心律患者。主要结局是住院期间发生POAF，定义为任何记录到的持续时间>30秒的房颤发作。使用单变量和多变量逻辑回归分析研究主要结局的预测因素。：在研究的400例患者（年龄68[61 - 73]岁，女性64例[16%]）中，66例（16.5%）发生了POAF。在检查的变量中，POAF的唯一预测因素是体外循环时间（比值比[OR]=1.001，95%置信区间=[95%CI，1.000 - 1.001]，P = -0.031）和癌症（OR = 3.852，95%CI = [1.535 - 9.664]，P = 0.004）。分别有13例（4%）无POAF患者和10例（15%）有POAF患者存在癌症（P<0.001）。：在本研究中，癌症与择期心脏手术后早期POAF风险的显著增加相关。心脏手术后发生POAF的患者是否应筛查癌症值得进一步研究。
