Hida Noriko, Serizawa Fuka, Sambe Takehiko, Nakamura Akihiro, Harada Tsutomu
Department of Clinical Research and Development, Graduate School of Pharmacy, Showa University, Tokyo 157-8577, Japan.
Department of Pharmaceutics, Graduate School of Pharmacy, Showa University, Tokyo 157-8577, Japan.
Pharmaceutics. 2025 Mar 5;17(3):333. doi: 10.3390/pharmaceutics17030333.
: Mini-tablets are a novel pediatric dosage form designed to mask drug taste and facilitate easier administration. This study aimed to assess the feasibility and acceptability of uncoated acetylsalicylic acid (ASA) mini-tablets in Japanese children with Kawasaki disease (KD) aged 1 to 4 years. : A retrospective case series study of three pediatric patients with KD treated with ASA mini-tablets (3 mm diameter, 10 mg) was conducted at Showa University Hospital. ASA mini-tablets were administered for up to 68 days. Caregivers recorded daily medication intake and any issues in medication logbooks. : All three patients successfully took 100% of the prescribed doses. No adverse events related to mini-tablet ingestion were reported. Patients could take the mini-tablets for extended periods (63-68 days) as part of their KD treatment. : ASA mini-tablets showed potential acceptability in this small cohort of pediatric patients with KD. This study represents the first investigation into the acceptability of mini-tablets containing active ingredients in Japanese pediatric patients. Larger studies are needed to confirm these findings and evaluate long-term safety and efficacy.
迷你片是一种新型儿科剂型，旨在掩盖药物味道并便于给药。本研究旨在评估未包衣的乙酰水杨酸（ASA）迷你片在1至4岁日本川崎病（KD）患儿中的可行性和可接受性。
在昭和大学医院对3例接受ASA迷你片（直径3毫米，10毫克）治疗的KD儿科患者进行了一项回顾性病例系列研究。ASA迷你片给药长达68天。护理人员在用药日志中记录每日用药情况和任何问题。
所有3例患者均成功服用了100%的规定剂量。未报告与服用迷你片相关的不良事件。作为KD治疗的一部分，患者能够长时间（63 - 68天）服用迷你片。
ASA迷你片在这一小群KD儿科患者中显示出潜在的可接受性。本研究是对日本儿科患者中含有活性成分的迷你片可接受性的首次调查。需要开展更大规模的研究来证实这些发现并评估长期安全性和有效性。
