Teo Zi Yi, Senthilkumar Samyuktha Dhanalakshmi, Srinivasan Dinesh Kumar
Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117597, Singapore.
Department of Anatomy, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 117594, Singapore.
Pharmaceutics. 2025 Mar 19;17(3):389. doi: 10.3390/pharmaceutics17030389.
Adhesions are the body's natural response to various inflammatory causes, with surgery being the most common cause. However, the formation of postoperative adhesions can lead to significant complications, including intestinal obstruction and chronic pain. To prevent such postoperative complications associated with adhesions, developing effective strategies for adhesion prevention has been a major focus of research. Currently, several therapeutic models have been developed to achieve this objective. These include pharmaceuticals, inert polymers, functional biomaterials, and nanotherapeutics. Among the various strategies developed, nanotherapeutics, though still in its early stages, has shown promise as a potential approach. Other therapeutic models are associated with adverse side effects and complications related to their application. On the other hand, nanotherapeutic models are able to overcome the limitations of the other strategies and provide their own set of unique advantages. Hence, nanotherapeutics represents a promising area for further research. Further efforts should be made to refine existing nanotherapeutics for clinical application while also addressing associated safety and ethical concerns related to their use in medical practice. Therefore, this article aims to review the various nanotherapeutic approaches developed for the prevention of postoperative adhesions, explore their regulatory pathways, and discuss associated safety and ethical concerns.
粘连是身体对各种炎症原因的自然反应，其中手术是最常见的原因。然而，术后粘连的形成会导致严重的并发症，包括肠梗阻和慢性疼痛。为了预防与粘连相关的术后并发症，开发有效的粘连预防策略一直是研究的主要重点。目前，已经开发了几种治疗模型来实现这一目标。这些包括药物、惰性聚合物、功能性生物材料和纳米治疗剂。在已开发的各种策略中，纳米治疗剂虽然仍处于早期阶段，但已显示出作为一种潜在方法的前景。其他治疗模型与其应用相关的不良副作用和并发症有关。另一方面，纳米治疗模型能够克服其他策略的局限性，并提供其自身独特的优势。因此，纳米治疗学是一个有前景的进一步研究领域。应进一步努力改进现有的纳米治疗剂以用于临床应用，同时解决与其在医学实践中的使用相关的安全和伦理问题。因此，本文旨在综述为预防术后粘连而开发的各种纳米治疗方法，探讨其监管途径，并讨论相关的安全和伦理问题。
