Macom Rhiannon V, Brown Candice M
Department of Microbiology, Immunology and Cell Biology, West Virginia University School of Medicine, Morgantown, WV 26506, USA.
Department of Neuroscience, Rockefeller Neuroscience Institute, West Virginia University School of Medicine, Morgantown, WV 26506, USA.
Pharmaceuticals (Basel). 2025 Feb 25;18(3):320. doi: 10.3390/ph18030320.
Although strokes originate in the brain, it is now widely appreciated that peripheral organ systems are also impacted by stroke. The gastrointestinal system is one peripheral organ system that is impaired during ischemic stroke. This impairment results in numerous complications, which impede post-stroke recovery. Many of the gastrointestinal mechanisms that contribute to the pathophysiology of ischemic stroke remain poorly understood. This review will highlight the molecular and cellular mechanisms underlying gastrointestinal outcomes in stroke by focusing on the complex interactions that largely occur in the small intestine. The final portion of this review will focus on therapeutic interventions that target the gut as a strategy to prevent or delay functional impairment and cognitive disability in stroke patients.
尽管中风起源于大脑，但现在人们普遍认识到，外周器官系统也会受到中风的影响。胃肠道系统是缺血性中风期间受损的外周器官系统之一。这种损伤会导致许多并发症，从而阻碍中风后的恢复。许多导致缺血性中风病理生理过程的胃肠道机制仍未被充分了解。本综述将通过关注主要发生在小肠中的复杂相互作用，重点阐述中风后胃肠道结果的分子和细胞机制。本综述的最后一部分将重点介绍针对肠道的治疗干预措施，作为预防或延缓中风患者功能障碍和认知残疾的一种策略。
