de Beer Anna, Han Chaeyoon, Sullivan Frank
School of Medicine, University of St Andrews, Fife, Scotland.
Yong Loo Lin School of Medicine, National University of Singapore, Singapore.
JBI Evid Synth. 2025 Jul 1;23(7):1493-1500. doi: 10.11124/JBIES-24-00253. Epub 2025 Mar 27.
The objective of the review is to systematically map the literature on non-pharmacological interventions for postural orthostatic tachycardia syndrome to identify and categorize interventions used, and highlight research gaps to guide future studies.
Postural orthostatic tachycardia syndrome is characterized by an excessive increase in heart rate upon standing and symptoms of orthostatic intolerance. Non-pharmacological interventions are first-line treatments; however, the breadth, characteristics, and gaps in the current evidence base have not been systematically mapped, making this scoping review necessary to guide future research directions.
Studies on non-drug, non-procedural, and non-invasive interventions for postural orthostatic tachycardia syndrome in both children and adults will be included. Direct (affecting patients) and indirect (benefiting but not targeting patients) interventions in any setting will be considered. Original research, systematic reviews, meta-analyses, and gray literature will be included.
A comprehensive search will be conducted across 6 databases (MEDLINE [Ovid], Embase [Ovid], Cochrane Library, CINAHL [EBSCOhost], Scopus, and Web of Science Core Collection) and gray literature platforms. Searches will be limited to articles in English, Afrikaans, French, German, and Korean, with no restriction on publication date. Two reviewers will independently screen titles and abstracts, as well as full texts, against the eligibility criteria. Data will be extracted using a standardized tool and presented to highlight key findings and research gaps. The initial data extraction form was developed after scanning the literature and will be iteratively refined as part of protocol development.
OSF https://osf.io/cg365.
本综述的目的是系统梳理关于体位性直立性心动过速综合征非药物干预措施的文献，以识别和分类所采用的干预措施，并突出研究空白，为未来研究提供指导。
体位性直立性心动过速综合征的特征是站立时心率过度增加以及直立不耐受症状。非药物干预是一线治疗方法；然而，目前证据基础的广度、特征和空白尚未得到系统梳理，因此有必要进行这项范围综述以指导未来的研究方向。
将纳入关于儿童和成人体位性直立性心动过速综合征的非药物、非手术和非侵入性干预措施的研究。任何环境下的直接（影响患者）和间接（使患者受益但并非针对患者）干预措施都将被考虑。原始研究、系统评价、荟萃分析和灰色文献都将被纳入。
将在6个数据库（MEDLINE [Ovid]、Embase [Ovid]、Cochrane图书馆、CINAHL [EBSCOhost]、Scopus和Web of Science核心合集）以及灰色文献平台上进行全面检索。检索将限于英文、南非荷兰语、法语、德语和韩语的文章，对发表日期无限制。两名评审员将根据纳入标准独立筛选标题和摘要以及全文。将使用标准化工具提取数据，并呈现以突出关键发现和研究空白。初始数据提取表是在浏览文献后制定的，并将作为方案制定的一部分进行迭代完善。
OSF https://osf.io/cg365 。
