Agrawal Sujata, Paul Paramita
Department of Pathology, HBCH Varanasi and MPMMMCC, Varanasi, 221005 UP India.
Indian J Thorac Cardiovasc Surg. 2025 Apr;41(4):468-473. doi: 10.1007/s12055-024-01826-2. Epub 2024 Sep 26.
Large cell neuroendocrine carcinoma (LCNEC) in the lung is an uncommon and highly aggressive type of histological variation, representing only a small percentage of all lung cancer cases. The occurrence of combined LCNEC, distinguished by the coexistence of neuroendocrine and non-neuroendocrine elements within a single tumor, is even more infrequent. A 49-year-old male presented with lytic lesion of the mandible with suspected lung metastasis. Biopsy of the mandibular lesion was reported as ameloblastic fibroma. The biopsy of the lung lesion turned out to be combined LCNEC of the lung. Further positron emission tomography (PET) evaluation showed multiple metastatic deposits in bilateral lungs, mediastinal nodes, liver, bone, adrenal, and kidney. The patient has received seven cycles of paclitaxel and carboplatin with decrease in size of nodes and lesion post 6 months. Herein, we report a case of combined LCNEC with lung adenocarcinoma which is infrequently encountered and has been a subject of research with a brief review of literature.
肺大细胞神经内分泌癌（LCNEC）是一种罕见且侵袭性很强的组织学变异类型，在所有肺癌病例中所占比例很小。合并性LCNEC的发生更为罕见，其特征是在单个肿瘤内同时存在神经内分泌和非神经内分泌成分。一名49岁男性因下颌骨溶骨性病变伴疑似肺转移就诊。下颌骨病变活检报告为成釉细胞纤维瘤。肺部病变活检结果为合并性肺LCNEC。进一步的正电子发射断层扫描（PET）评估显示双侧肺、纵隔淋巴结、肝脏、骨骼、肾上腺和肾脏有多处转移灶。该患者接受了七个周期的紫杉醇和卡铂治疗，6个月后淋巴结和病变大小减小。在此，我们报告一例合并性LCNEC与肺腺癌的病例，这种情况很少见，并且是一个研究课题，并对相关文献进行简要综述。
