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清醒豚鼠的胃肠肌电活动

Gastrointestinal myoelectric activity in conscious guinea pigs.

作者信息

Galligan J J, Costa M, Furness J B

出版信息

Am J Physiol. 1985 Jul;249(1 Pt 1):G92-9. doi: 10.1152/ajpgi.1985.249.1.G92.

DOI:10.1152/ajpgi.1985.249.1.G92
PMID:4014468
Abstract

Myoelectric activity was recorded from the gastric antrum and small intestine of conscious, unrestrained guinea pigs using bipolar Ag-Ag chloride electrodes that had been previously implanted under pentobarbital sodium/Innovar anesthesia. In fasted guinea pigs, the migrating myoelectric complex (MMC) was recorded from the small intestine and was observed to propagate aborally at a speed that declined with distance from the pylorus (range of speeds of the front of phase 3: 17.5 cm/min in the duodenum to 4.1 cm/min in the ileum). The complex was not disrupted by feeding but occurred less frequently in the freely fed state (82-min cycle period in the fasted state versus 139 min in the fed state). The complex started in the duodenum and was accompanied by a brief (6.3 +/- 0.9 min) period of inhibition of antral myoelectric activity. Slow waves were also recorded from the gastric antrum (10.3 +/- 1.3/min) and the small intestine. The frequency of intestinal slow waves was uniform along the length of the bowel (26.2 +/- 1.3/min in the duodenum to 24.7 +/- 1.3/min in the ileum). It is concluded that the guinea pig is similar to other mammalian species, so far examined, in its pattern of gastrointestinal myoelectric activity.

摘要

使用先前在戊巴比妥钠/ Innovar麻醉下植入的双极银 - 氯化银电极,记录清醒、不受束缚的豚鼠胃窦和小肠的肌电活动。在禁食的豚鼠中,从小肠记录到移行性肌电复合波(MMC),观察到其以一种随着距幽门距离增加而下降的速度向口外传播(第3相波锋速度范围:十二指肠为17.5厘米/分钟,回肠为4.1厘米/分钟)。该复合波不受进食干扰,但在自由进食状态下发生频率较低(禁食状态下周期为82分钟,进食状态下为139分钟)。该复合波始于十二指肠,并伴有胃窦肌电活动短暂(6.3±0.9分钟)的抑制期。胃窦(10.3±1.3次/分钟)和小肠也记录到慢波。肠道慢波频率沿肠管长度一致(十二指肠为26.2±1.3次/分钟,回肠为24.7±1.3次/分钟)。结论是,就其胃肠肌电活动模式而言,豚鼠与迄今所研究的其他哺乳动物相似。

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Initiation of peristalsis by circumferential stretch of flat sheets of guinea-pig ileum.通过豚鼠回肠扁平片的周向拉伸引发蠕动。
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