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硅化姜黄素微球通过Nrf2/HO-1途径对抗心血管疾病。

Silicified curcumin microspheres Combats cardiovascular diseases via Nrf2/HO-1 pathway.

作者信息

Guan Tianwang, Lu Zhenxing, Tai Rundong, Guo Shuai, Zhang Zhaowenbin, Deng Shaohui, Ye Jujian, Chi Kaiyi, Zhang Binghua, Chen Huiwan, Deng Zhilin, Ke Yushen, Huang Andong, Chen Peier, Wang Chunming, Ou Caiwen

机构信息

Guangdong Engineering Research Center of Boron Neutron Therapy and Application in Malignant Tumors, Dongguan Key Laboratory of Precision Diagnosis and Treatment for Tumors, Dongguan Engineering Research Center for Innovative Boron Drugs and Novel Radioimmune Drugs, Cancer Center, The 10th Affiliated Hospital of Southern Medical University (Dongguan People's Hospital), Southern Medical University, Guangdong, 523059, China.

Guangdong Provincial Key Laboratory of Cardiac Function and Microcirculation, Guangzhou, 510280, China.

出版信息

Bioact Mater. 2025 Mar 15;49:378-398. doi: 10.1016/j.bioactmat.2025.03.007. eCollection 2025 Jul.

DOI:10.1016/j.bioactmat.2025.03.007
PMID:40144796
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11937612/
Abstract

Diabetes and chemotherapy frequently give rise to severe cardiovascular complications, including chemotherapy-induced cardiotoxicity and diabetes-associated vascular remodeling. Nevertheless, the precise epidemiological features of these cardiovascular ailments remain incompletely elucidated, resulting in a dearth of effective therapeutic strategies in clinical settings. To tackle this intricate challenge, we have delved extensively into database resources, conducted comprehensive analyses of pertinent epidemiological data, and designed silicified curcumin (Si/Cur) microspheres as a novel therapeutic approach for cardiovascular diseases. By harnessing the alkaline microenvironment generated by silicon (Si), Si/Cur markedly elevates the bioavailability of curcumin (Cur). Further investigations have elucidated that Si/Cur exerts its therapeutic actions primarily via the Nrf2/HO-1 signaling pathway, effectively suppressing vascular remodeling and mitigating myocardial injury, thus disrupting the vicious cycle of persistent cardiovascular damage. In conclusion, this study integrates clinical cohort research to dissect epidemiological characteristics, directs the design and application of biomaterials, and paves the way for a novel and efficacious therapeutic avenue for the management of cardiovascular diseases.

摘要

糖尿病和化疗常常引发严重的心血管并发症,包括化疗诱导的心脏毒性和糖尿病相关的血管重塑。然而,这些心血管疾病的确切流行病学特征仍未完全阐明,导致临床环境中缺乏有效的治疗策略。为应对这一复杂挑战,我们深入研究了数据库资源,对相关流行病学数据进行了全面分析,并设计了硅化姜黄素(Si/Cur)微球作为心血管疾病的一种新型治疗方法。通过利用硅(Si)产生的碱性微环境,Si/Cur显著提高了姜黄素(Cur)的生物利用度。进一步的研究表明,Si/Cur主要通过Nrf2/HO-1信号通路发挥其治疗作用,有效抑制血管重塑并减轻心肌损伤,从而打破持续心血管损伤的恶性循环。总之,本研究整合临床队列研究以剖析流行病学特征,指导生物材料的设计与应用,并为心血管疾病管理开辟了一条新颖且有效的治疗途径。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/70c4d87b02d1/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/b6505e51ed5d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/89b0a19a9f9e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/f914799fad62/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/4b3988dd087a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/ee8d68c9512d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/dfa3346f79d1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/8cdeba7d540d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/08d40c64cbb0/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/07923ec3fd7d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/70c4d87b02d1/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/b6505e51ed5d/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/89b0a19a9f9e/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/f914799fad62/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/4b3988dd087a/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/ee8d68c9512d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/dfa3346f79d1/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/8cdeba7d540d/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/08d40c64cbb0/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/07923ec3fd7d/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abe2/11937612/70c4d87b02d1/gr9.jpg

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