Huang Fangchang, Zhu Xin, Liang Xinglong
The First Clinical College of Medicine, Guangdong Medical University, Zhanjiang, Guangdong, China.
Department of Dermatology, Maoming People's Hospital, Maoming, Guangdong, China.
Front Med (Lausanne). 2025 Mar 12;12:1539386. doi: 10.3389/fmed.2025.1539386. eCollection 2025.
Atopic dermatitis (AD) is a chronic, pruritic, inflammatory skin condition that imposes significant psychological and economic burdens on patients due to its recurring nature. Its etiology is multifactorial, involving interactions between genetic predispositions and environmental factors. The skin barrier serves as both a mechanical and immunological defense, and its structural damage and functional impairments significantly contribute to the pathogenesis of AD. This study aims to explore the future prospects and developmental trends of the skin barrier in the context of AD through a bibliometric analysis.
To analyze the research status, hot spots and development trend of skin barrier in AD.
Relevant studies were extracted from the Web of Science database and screened by researchers, with bibliometric analysis conducted using VOSviewer, CiteSpace, and other tools.
A total of 4,227 publications were identified over a 24-year research period. The United States is the leading contributor, with 1,263 publications, and demonstrates extensive collaboration with numerous countries. The journal with the highest number of publications is the Journal of Allergy and Clinical Immunology. The most prolific institutions is the University of California, San Francisco. Recent years have seen high citation intensity for keywords such as "dupilumab," "barrier dysfunction," and "gut microbiota".
The mechanism of the skin barrier in AD remains an area requiring ongoing research and analysis. Although significant progress has been achieved, future research will benefit from advancements in technology.
特应性皮炎（AD）是一种慢性、瘙痒性炎症性皮肤病，因其复发性给患者带来了巨大的心理和经济负担。其病因是多因素的，涉及遗传易感性和环境因素之间的相互作用。皮肤屏障兼具机械和免疫防御功能，其结构损伤和功能障碍在AD的发病机制中起重要作用。本研究旨在通过文献计量分析探讨AD背景下皮肤屏障的未来前景和发展趋势。
分析AD中皮肤屏障的研究现状、热点及发展趋势。
从科学网数据库中提取相关研究，并由研究人员进行筛选，使用VOSviewer、CiteSpace等工具进行文献计量分析。
在24年的研究期间共确定了4227篇出版物。美国是主要贡献者，有1263篇出版物，并与许多国家开展了广泛合作。发表文章数量最多的期刊是《过敏与临床免疫学杂志》。发文量最多的机构是加利福尼亚大学旧金山分校。近年来，“度普利尤单抗”“屏障功能障碍”和“肠道微生物群”等关键词的被引强度较高。
AD中皮肤屏障的机制仍是一个需要持续研究和分析的领域。尽管已取得重大进展，但未来的研究将受益于技术进步。
