Goodnight J E, Bargar W L, Voegeli T, Blaisdell F W
Am J Surg. 1985 Jul;150(1):109-13. doi: 10.1016/0002-9610(85)90018-2.
Complete local control of 25 extremity bone and soft tissue sarcomas was obtained by combined preoperative intraarterial doxorubicin and radiation therapy, followed by limb-sparing resection with reconstruction and adjuvant chemotherapy. At a 32 month median follow-up, there are no local tumor recurrences. Functional limbs were salvaged in 21 patients (84 percent). Fifteen patients (60 percent) were continuously disease-free and overall survival was 80 percent. After the extensive combined modality therapy, extremity complications, including delays in wound healing, occurred in 10 patients. Nevertheless, most complications were resolved with salvage of functional limbs. These results support an aggressive multimodality limb-sparing approach to high-grade extremity sarcomas.
通过术前动脉内给予阿霉素和放射治疗相结合，随后进行保肢切除、重建及辅助化疗，25例肢体骨肉瘤和软组织肉瘤均实现了局部完全控制。中位随访32个月时，无局部肿瘤复发。21例患者（84%）的肢体功能得以保留。15例患者（60%）持续无病生存，总生存率为80%。在广泛的综合治疗后，10例患者出现了包括伤口愈合延迟在内的肢体并发症。然而，大多数并发症通过保留肢体功能得到了解决。这些结果支持对高级别肢体肉瘤采用积极的多模式保肢方法。
