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Immunoproteasome as a therapeutic target in obesity-related brain inflammation and metabolic disorders.

作者信息

Álvarez-Indo Javiera, Albornoz Nicolás, Soza Andrea, Burgos Patricia V

机构信息

Centro de Biología Celular y Biomedicina, Facultad de Medicina y Ciencia, Universidad San Sebastián, Santiago, Chile (Álvarez-Indo J, Albornoz N, Soza A, Burgos PV).

Centro Basal Ciencia & Vida, Universidad San Sebastián, Santiago, Chile (Soza A, Burgos PV).

出版信息

Neural Regen Res. 2026 Apr 1;21(4):1554-1555. doi: 10.4103/NRR.NRR-D-24-01358. Epub 2025 Mar 25.

DOI:10.4103/NRR.NRR-D-24-01358
PMID:40145949
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12407525/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e5/12407525/1b7b575f8273/NRR-21-1554-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e5/12407525/1b7b575f8273/NRR-21-1554-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/01e5/12407525/1b7b575f8273/NRR-21-1554-g001.jpg

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本文引用的文献

1
Immunoproteasome acted as immunotherapy 'coffee companion' in advanced carcinoma therapy.免疫蛋白酶体在晚期癌症治疗中充当免疫疗法的“咖啡伴侣”。
Front Immunol. 2024 Aug 30;15:1464267. doi: 10.3389/fimmu.2024.1464267. eCollection 2024.
2
Targeting the immunoproteasome in hypothalamic neurons as a novel therapeutic strategy for high-fat diet-induced obesity and metabolic dysregulation.针对下丘脑神经元中的免疫蛋白酶体作为治疗高脂肪饮食诱导肥胖和代谢紊乱的新策略。
J Neuroinflammation. 2024 Aug 2;21(1):191. doi: 10.1186/s12974-024-03154-z.
3
Immunoproteasomal Inhibition With ONX-0914 Attenuates Atherosclerosis and Reduces White Adipose Tissue Mass and Metabolic Syndrome in Mice.
免疫蛋白酶体抑制 ONX-0914 可减轻动脉粥样硬化并减少小鼠白色脂肪组织质量和代谢综合征。
Arterioscler Thromb Vasc Biol. 2024 Jun;44(6):1346-1364. doi: 10.1161/ATVBAHA.123.319701. Epub 2024 Apr 25.
4
Correction: Immunoproteasome Subunit Low Molecular Mass Peptide 2 (LMP2) Deficiency Ameliorates LPS/Aβ1-42-Induced Neuroinflammation.更正：免疫蛋白酶体亚基低分子量肽2（LMP2）缺乏减轻LPS/Aβ1-42诱导的神经炎症。
Mol Neurobiol. 2024 Oct;61(10):8481-8482. doi: 10.1007/s12035-024-03972-5.
5
Immunoproteasome Subunit Low Molecular Mass Peptide 2 (LMP2) Deficiency Ameliorates LPS/Aβ-Induced Neuroinflammation.免疫蛋白酶体亚基低分子量多肽 2（LMP2）缺乏可改善 LPS/Aβ 诱导的神经炎症。
Mol Neurobiol. 2024 Jan;61(1):28-41. doi: 10.1007/s12035-023-03564-9. Epub 2023 Aug 12.
6
LMP2 deficiency causes abnormal metabolism, oxidative stress, neuroinflammation, myelin loss and neurobehavioral dysfunctions.LMP2 缺乏会导致代谢异常、氧化应激、神经炎症、髓鞘丢失和神经行为功能障碍。
J Transl Med. 2023 Mar 28;21(1):226. doi: 10.1186/s12967-023-04071-0.
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Obesity-induced elevated palmitic acid promotes inflammation and glucose metabolism disorders through GPRs/NF-κB/KLF7 pathway.肥胖诱导的高棕榈酸通过 GPRs/NF-κB/KLF7 通路促进炎症和葡萄糖代谢紊乱。
Nutr Diabetes. 2022 Apr 20;12(1):23. doi: 10.1038/s41387-022-00202-6.
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Immunoproteasome subunit PSMB8 regulates microglia-mediated neuroinflammation upon manganese exposure by PERK signaling.免疫蛋白酶体亚基 PSMB8 通过 PERK 信号调节锰暴露诱导的小胶质细胞介导的神经炎症。
Food Chem Toxicol. 2022 May;163:112951. doi: 10.1016/j.fct.2022.112951. Epub 2022 Apr 1.
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LMP2 Inhibitors as a Potential Treatment for Alzheimer's Disease.LMP2 抑制剂作为治疗阿尔茨海默病的一种潜在疗法。
J Med Chem. 2020 Apr 9;63(7):3763-3783. doi: 10.1021/acs.jmedchem.0c00416. Epub 2020 Mar 30.
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Inhibiting the immunoproteasome exacerbates the pathogenesis of systemic Candida albicans infection in mice.抑制免疫蛋白酶体可加剧小鼠系统性白色念珠菌感染的发病机制。
Sci Rep. 2016 Jan 18;6:19434. doi: 10.1038/srep19434.