Meseha Mina, Patel Vishw, Sekla Kirolos, Yang Ping, Coffey David
University of Miami, Miami, USA.
Cleveland Clinic, Cleveland, USA.
J Hematop. 2025 Mar 27;18(1):11. doi: 10.1007/s12308-025-00626-w.
Multiple myeloma is a clonal plasma cell malignancy often characterized by complex cytogenetic abnormalities that influence prognosis and treatment strategies. This report describes a 63-year-old male with kappa light chain multiple myeloma and a rare finding of double translocation involving t(11;14) and t(14;16), detected by FISH analysis. This case emphasizes the clinical implications of such genetic abnormalities and their impact on disease progression and therapeutic decisions.
多发性骨髓瘤是一种克隆性浆细胞恶性肿瘤，通常具有影响预后和治疗策略的复杂细胞遗传学异常。本报告描述了一名63岁男性，患有κ轻链多发性骨髓瘤，通过荧光原位杂交（FISH）分析检测到罕见的涉及t(11;14)和t(14;16)的双易位。该病例强调了此类基因异常的临床意义及其对疾病进展和治疗决策的影响。
