Weininger Gabe, Elde Stefan, Zhu Yuanjia, Woo Y Joseph
Department of Cardiothoracic Surgery, Falk Cardiovascular Research Center, Stanford University School of Medicine, 300 Pasteur Drive, Stanford, CA, 94305, USA.
Department of Bioengineering, Stanford University, Stanford, CA, USA.
Gen Thorac Cardiovasc Surg. 2025 Jun;73(6):375-384. doi: 10.1007/s11748-025-02127-0. Epub 2025 Mar 27.
The increase in prevalence of valvular heart disease coupled with an aging population has placed increased emphasis on durable valvular repair strategies. Despite many advances in valvular therapies, there has been little rigorous biomechanical evaluation and validation of existing repair strategies. Our research group engineered a novel 3D-printed, ex vivo heart simulator, which has allowed us to refine and innovate numerous surgical repair strategies with hemodynamic and biomechanical feedback in real time on explanted animal heart valves. Data obtained from this novel simulator have directly influenced clinical practice at our institution. It has also proven to be an outstanding platform for valvular device development. Herein, we will review our experience with ex vivo biomechanical simulation, subdivided into work on aortic valve pathology, mitral valve pathology, and novel devices.
心脏瓣膜疾病患病率的上升以及人口老龄化，使得人们越来越重视耐用的瓣膜修复策略。尽管瓣膜治疗取得了许多进展，但对现有修复策略的严格生物力学评估和验证却很少。我们的研究小组设计了一种新型的3D打印体外心脏模拟器，这使我们能够在离体动物心脏瓣膜上实时获得血流动力学和生物力学反馈，从而完善和创新多种手术修复策略。从这个新型模拟器获得的数据直接影响了我们机构的临床实践。它也被证明是瓣膜装置开发的一个出色平台。在此，我们将回顾我们在体外生物力学模拟方面的经验，分为主动脉瓣病变、二尖瓣病变和新型装置的研究。
