Ravussin P, Bayer-Berger M M
Ann Fr Anesth Reanim. 1985;4(3):254-7. doi: 10.1016/s0750-7658(85)80135-0.
The quality of recovery and the time required for it were compared in two groups of 20 patients after general anaesthesia with isoflurane or halothane for elective head and neck surgery. The groups were comparable with regard to age, sex ratio, ASA physical status, type of surgery and duration of anaesthesia. After premedication with diazepam and atropine, a standard induction technique was used (thiopentone, succinylcholine), avoiding opiates and sedatives. Maintenance was assured with a mixture of 30% oxygen, 70% nitrous oxide and isoflurane or halothane. The time between the end of administration of anaesthetic drugs and eye opening was 7.15 +/- 2.9 min in the isoflurane group, and 11.0 +/- 4.7 min in the halothane group (p less than 0.01). The differences between the times for the return of spatial and temporal orientation and of mental arithmetic were not significant, though they were clinically clearly perceptible. The patients were less sleepy, livelier and less agitated in the isoflurane group in the first hour of recovery. Recovery was more rapid after general anaesthesia with isoflurane, and of better clinical quality.
在两组各20例择期进行头颈手术的患者中，比较了异氟烷或氟烷全身麻醉后恢复质量及恢复所需时间。两组在年龄、性别比、美国麻醉医师协会（ASA）身体状况、手术类型及麻醉持续时间方面具有可比性。在用地西泮和阿托品进行术前用药后，采用标准诱导技术（硫喷妥钠、琥珀酰胆碱），避免使用阿片类药物和镇静剂。用30%氧气、70%氧化亚氮与异氟烷或氟烷的混合气体维持麻醉。异氟烷组麻醉药物给药结束至睁眼的时间为7.15±2.9分钟，氟烷组为11.0±4.7分钟（p<0.01）。空间和时间定向恢复及心算恢复时间的差异虽无统计学意义，但临床上明显可感知。在恢复的第一小时，异氟烷组患者困倦感较轻、更活跃且躁动较少。异氟烷全身麻醉后的恢复更快，临床质量更好。
