Dan Kazuhiro, Witberg Guy, Itabashi Fumiharu, Maeda Takuya, Kikuta Yuetsu, Okabe Kouya, Tanigaki Toru, Nanasato Mamoru, Hikichi Yutaka, Yokoi Hiroyoshi, Kornowski Ran, Matsuo Hitoshi
Ichinomiyanishi Hospital, Aichi, Japan.
Rabin Medical Center, Petach-Tikva, Israel.
Cardiovasc Revasc Med. 2025 Sep;78:80-85. doi: 10.1016/j.carrev.2025.03.012. Epub 2025 Mar 18.
The diagnostic performance of an angiogram-based physiological assessment system (FFRangio™, CathWorks) has been already demonstrated. Besides performing a functional assessment, the FFRangio system provides a 3-dimensional quantitative coronary angiogram-based sizing tool (FFRangioST) to measure lumen diameter and vessel length. We aim to compare the measurements obtained using FFRangioST against measurements obtained with intravascular ultrasound (IVUS) in patients undergoing percutaneous coronary intervention (PCI).
We analyzed data from consecutive patients who underwent IVUS-guided PCI after FFRangio physiological assessment and FFRangioST assessment of lesion diameters and length from the Japan FFRangio clinical outcome registry (ClinicalTrials.gov. NCT05648396). For each lesion undergoing PCI, the correlation and mean difference for lesion length (LL), proximal reference diameter (RD) and distal RD as measured by FFRangioST/IVUS were assessed using pairwise comparisons, Pearson's correlation and Bland-Altman plots.
Our cohort included 121 lesions from 115 patients. The FFRangio value in this cohort was 0.60 ± 0.1 (mean ± standard deviation). Mean LL (mm) was 31.1 ± 13.9 and 30.3 ± 14.3 by FFRangioST and IVUS, respectively. Correlation between the LL measurements was r = 0.986 (p < 0.001). Proximal RD (mm) was 2.6 ± 0.5 and 3.2 ± 0.6 by FFRangioST and IVUS, respectively, with correlation of r = 0.756 (p < 0.001). Distal RD (mm) was 2.2 ± 0.5 and 2.7 ± 0.5 by FFRangioST and IVUS, respectively, with correlation of r = 0.832 (p < 0.001). After inflating the original FFRangioST diameter value by 25 %, the average difference between the IVUS and FFRangioST measurements was 0.02 mm and -0.02 mm, for proximal and distal RD, respectively.
FFRangioST measurement has an excellent correlation with lesion length and high degree of correlation with a predictable coefficient (25 % inflation) with proximal and distal reference diameters when compared with IVUS measurement in PCI.
基于血管造影的生理评估系统（FFRangio™，CathWorks）的诊断性能已经得到证实。除了进行功能评估外，FFRangio系统还提供一种基于三维定量冠状动脉造影的测量工具（FFRangioST），用于测量管腔直径和血管长度。我们旨在比较接受经皮冠状动脉介入治疗（PCI）的患者使用FFRangioST获得的测量结果与血管内超声（IVUS）获得的测量结果。
我们分析了来自日本FFRangio临床结局登记处（ClinicalTrials.gov. NCT05648396）的连续患者的数据，这些患者在进行FFRangio生理评估以及对病变直径和长度进行FFRangioST评估后接受了IVUS引导的PCI。对于每个接受PCI的病变，使用配对比较、Pearson相关性分析和Bland-Altman图评估FFRangioST/IVUS测量的病变长度（LL）、近端参考直径（RD）和远端RD的相关性和平均差异。
我们的队列包括来自115名患者的121个病变。该队列中的FFRangio值为0.60±0.1（平均值±标准差）。FFRangioST和IVUS测量的平均LL（mm）分别为31.1±13.9和30.3±14.3。LL测量之间的相关性为r = 0.986（p < 0.001）。FFRangioST和IVUS测量的近端RD（mm）分别为2.6±0.5和3.2±0.6，相关性为r = 0.756（p < 0.001）。FFRangioST和IVUS测量的远端RD（mm）分别为2.2±0.5和2.7±0.5，相关性为r = 0.832（p < 0.001）。将原始FFRangioST直径值增大25%后，IVUS与FFRangioST测量的近端和远端RD的平均差异分别为0.02 mm和 -0.02 mm。
在PCI中，与IVUS测量相比，FFRangioST测量与病变长度具有极好的相关性，与近端和远端参考直径具有高度相关性且系数可预测（增大25%）。
