Ramadhan Gilang Titah, Haris Fahni, Jan Yih-Kuen, Liau Ben-Yi, Shen Wei-Cheng, Bau Jian-Guo, Lien Chun-Ming, Tai Chien-Cheng, Lung Chi-Wen
Department of Computer Science and Information Engineering, Asia University, Taichung, 413305, Taiwan.
School of Nursing, Universitas Muhammadiyah Yogyakarta, Yogyakarta, 55183, Indonesia.
Sci Rep. 2025 Mar 27;15(1):10603. doi: 10.1038/s41598-025-94649-z.
To evaluate the impact of air insole on reducing the risk of diabetic foot ulcers (DFUs) in healthy individuals through microcirculation assessment, which considers blood flow as a critical factor due to the role of peripheral vascular disease in DFU development. The study analyzes the interaction between air insole pressure and walking duration. Repeated-measures design was used to assess the effects of two walking durations (10 and 20 min) and three air insole pressures (80, 160, and 240 mmHg), resulting in six walking conditions tested in 13 healthy participants. The average blood flow in the first metatarsal head (M1) was quantified using data from the last 3 min of the 10 min post-exercise period. The results of one-way ANOVA showed that the 80 mmHg air insole pressure was significantly lower microcirculation than 240 mmHg with 10 min walking duration (129.4 ± 9.1 vs 163.1 ± 12.6 PU, P = 0.035). The paired t-test showed three significant differences in the effects of the walking duration in all air insole pressures. (1) 10 min walking duration was significantly lower compared to 20 min with 80 mmHg air insole pressure (129.4 ± 9.1 vs 203.6 ± 10.1 PU, P = 0.001); (2) 10 min walking duration was significantly lower compared to 20 min with 160 mmHg air insole pressure (142.5 ± 10.6 vs 206.0 ± 12.5 PU, P = 0.001); (3) 10 min walking duration was significantly lower compared to 20 min with 240 mmHg (163.1 ± 12.6 vs 219.1 ± 11.8 PU, P = 0.008). This study highlights that walking with an air insole pressure of 80 mmHg for 20 minutes influences microcirculation at the first metatarsal head, potentially offering important benefits for individuals at risk of pressure-related injuries, such as DFUs.
通过微循环评估来评估空气鞋垫对降低健康个体患糖尿病足溃疡（DFU）风险的影响，由于外周血管疾病在DFU发展中的作用，该评估将血流视为关键因素。该研究分析了空气鞋垫压力与步行持续时间之间的相互作用。采用重复测量设计来评估两种步行持续时间（10分钟和20分钟）和三种空气鞋垫压力（80、160和240毫米汞柱）的影响，在13名健康参与者中测试了六种步行条件。使用运动后10分钟最后3分钟的数据对第一跖骨头（M1）的平均血流进行量化。单因素方差分析结果显示，在步行持续时间为10分钟时，80毫米汞柱的空气鞋垫压力下的微循环显著低于240毫米汞柱（129.4±9.1对163.1±12.6 PU，P = 0.035）。配对t检验显示，在所有空气鞋垫压力下，步行持续时间的影响存在三个显著差异。（1） 在空气鞋垫压力为80毫米汞柱时，步行10分钟的时间显著低于20分钟（129.4±9.1对203.6±10.1 PU，P = 0.001）；（2） 在空气鞋垫压力为160毫米汞柱时，步行10分钟的时间显著低于20分钟（142.5±10.6对206.0±12.5 PU，P = 0.001）；（3） 在空气鞋垫压力为240毫米汞柱时，步行10分钟的时间显著低于20分钟（163.1±12.6对219.1±11.8 PU，P = 0.008）。本研究强调，穿着压力为80毫米汞柱的空气鞋垫步行20分钟会影响第一跖骨头的微循环，这可能为有压力相关损伤风险的个体（如糖尿病足溃疡患者）带来重要益处。
