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What is radiation-induced acute myeloid leukaemia/can it be accurately identified?

作者信息

Badie Christophe, Gale Robert Peter

机构信息

Radiation Effects Department, Radiation, Chemicals, Climate and Environmental Hazards Directorate, UK Health Security Agency, Harwell campus, Chilton, Didcot, Oxfordshire, OX11 0RQ, UK.

Centre for Haematology, Imperial College of Science, Technology and Medicine, London, UK.

出版信息

Leukemia. 2025 Jun;39(6):1334-1336. doi: 10.1038/s41375-025-02561-2. Epub 2025 Mar 27.

DOI:10.1038/s41375-025-02561-2
PMID:40148557
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12133577/
Abstract
摘要

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本文引用的文献

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Mutations in Acute Leukemias and Myelodysplastic Syndromes: Insights and Treatment Updates.急性白血病和骨髓增生异常综合征中的突变：见解与治疗进展。
Am Soc Clin Oncol Educ Book. 2024 Jun;44(3):e432650. doi: 10.1200/EDBK_432650.
2
Quantitative and qualitative mutational impact of ionizing radiation on normal cells.电离辐射对正常细胞的定量和定性突变影响。
Cell Genom. 2024 Feb 14;4(2):100499. doi: 10.1016/j.xgen.2024.100499.
3
R235C point mutation confers hypersensitivity to radiation-induced acute myeloid leukemia in mice.R235C点突变使小鼠对辐射诱导的急性髓系白血病敏感。
iScience. 2023 Aug 3;26(9):107530. doi: 10.1016/j.isci.2023.107530. eCollection 2023 Sep 15.
4
Spectra and characteristics of somatic mutations induced by ionizing radiation in hematopoietic stem cells.电离辐射诱导造血干细胞体细胞突变的特征和特性。
Proc Natl Acad Sci U S A. 2023 Apr 11;120(15):e2216550120. doi: 10.1073/pnas.2216550120. Epub 2023 Apr 5.
5
Diagnosis and management of AML in adults: 2022 recommendations from an international expert panel on behalf of the ELN.成人 AML 的诊断与治疗：ELN 专家组代表发布的 2022 年国际专家建议
Blood. 2022 Sep 22;140(12):1345-1377. doi: 10.1182/blood.2022016867.
6
The 5th edition of the World Health Organization Classification of Haematolymphoid Tumours: Myeloid and Histiocytic/Dendritic Neoplasms.世界卫生组织血液淋巴肿瘤分类第五版：髓系和组织细胞/树突状肿瘤。
Leukemia. 2022 Jul;36(7):1703-1719. doi: 10.1038/s41375-022-01613-1. Epub 2022 Jun 22.
7
The critical roles of somatic mutations and environmental tumor-promoting agents in cancer risk.体细胞突变和环境肿瘤促进因素在癌症风险中的关键作用。
Nat Genet. 2020 Nov;52(11):1139-1143. doi: 10.1038/s41588-020-00727-5. Epub 2020 Oct 26.
8
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Carcinogenesis. 2020 Aug 12;41(8):1104-1112. doi: 10.1093/carcin/bgz175.
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Outcompeting p53-Mutant Cells in the Normal Esophagus by Redox Manipulation.通过氧化还原操纵在正常食管中战胜 p53 突变细胞。
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