Tepecik Tahsin, Zöngör Mert, Gedik Ecem
Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, University of Health Sciences, Uskudar, Istanbul, Turkey.
BMC Oral Health. 2025 Mar 27;25(1):445. doi: 10.1186/s12903-025-05824-7.
The aim of this study was to compare the therapeutic outcomes of single versus multiple injectable platelet-rich fibrin (i-PRF) injections after arthrocentesis in patients with temporomandibular joint osteoarthritis (TMJ-OA). The objective was to evaluate and compare TMJ pain and mobility at the 1st, 6th, and 12th months postoperatively.
This retrospective cohort study included 85 female patients (age: 31-73 years, mean ± sd: 54.9 ± 8.8) who underwent arthrocentesis with i-PRF injections from June 2018 to November 2021, diagnosed with osteoarthritis based on the Diagnostic Criteria for Temporomandibular Disorders (DC/TMD). Patients had no prior use of occlusal splint. During follow-up visits, pain was evaluated with a visual analog scale (pVAS) during function and maximum interincisal opening (MIO) was measured to assess jaw mobility. The study included patient follow-up records at four time points: preoperative (T0), 1 month postoperative (T1), 6 months postoperative (T2), and 12 months postoperative (T3). The primary outcome variable was pVAS at T3, secondary outcome variables were pVAS at T1 and T2, and MIO at T1, T2, and T3.
No significant differences were found in joint pain or mobility between groups at follow-ups (> 0.05).
Both groups showed similar outcomes in terms of pain and mobility over a 12-month period. Increasing the frequency of i-PRF injections does not appear to have an impact on therapeutic outcomes in patients with TMJOA. Given the retrospective design of this study, it is important to evaluate the results with caution.
本研究旨在比较颞下颌关节骨关节炎（TMJ-OA）患者关节穿刺术后单次注射与多次注射富血小板纤维蛋白（i-PRF）的治疗效果。目的是评估并比较术后第1、6和12个月时颞下颌关节的疼痛和活动度。
这项回顾性队列研究纳入了85名女性患者（年龄：31 - 73岁，平均±标准差：54.9 ± 8.8），她们在2018年6月至2021年11月期间接受了关节穿刺并注射i-PRF，根据颞下颌关节紊乱病诊断标准（DC/TMD）被诊断为骨关节炎。患者此前未使用过咬合板。在随访期间，通过视觉模拟量表（pVAS）评估功能时的疼痛情况，并测量最大切牙间开口度（MIO）以评估下颌活动度。该研究包括患者在四个时间点的随访记录：术前（T0）、术后1个月（T1）、术后6个月（T2）和术后12个月（T3）。主要结局变量是T3时的pVAS，次要结局变量是T1和T2时的pVAS，以及T1、T2和T3时的MIO。
随访时两组之间在关节疼痛或活动度方面未发现显著差异（> 0.05）。
在12个月期间，两组在疼痛和活动度方面显示出相似的结果。增加i-PRF注射频率似乎对TMJOA患者的治疗效果没有影响。鉴于本研究的回顾性设计，谨慎评估结果很重要。
