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儿童先天性二尖瓣疾病再次手术的结果。

The outcomes of reoperation for congenital mitral valve diseases in children.

作者信息

Cai Yixuan, Shan Yaping, Chen Gang, Mi Yaping, Zhong Hui, Zhang Huifeng, Ye Ming

机构信息

Department of Cardiothoracic Surgery, Children's Hospital of Fudan University, No. 399, Wanyuan Rd, Minhang District, Shanghai, China.

出版信息

BMC Surg. 2025 Mar 28;25(1):121. doi: 10.1186/s12893-025-02855-3.

Abstract

BACKGROUNDS

We aimed to study the outcomes of mitral valve (MV) reoperations in children with congenital MV diseases and to summarize our treatment experience.

METHODS

In this single-center retrospective study, we enrolled 24 patients aged < 18 years who underwent MV reoperation from among 265 patients who underwent MV repair between January 2013 and July 2023. MV reoperations were based on the types of MV disease. Cox regressions were used to analyze the risk factors for death and second MV reoperation.

RESULTS

A total of 5 patients underwent second MV reoperations. 3 patients experienced early death, and 1 experienced late death. The 3- and 5-year survival rates of the entire cohort were 86.6% ± 7.3% and 72.1% ± 14.5%, respectively. Patients who had the double-orifice MV technique applied during MV reoperation were significantly more prone to receive mechanical MV replacement (P < 0.0001). The use of double-orifice MV technique during MV reoperation was identified as an independent risk factor for second MV reoperation (HR = 8.136, 95%CI = 1.099-60.240; P = 0.040).

CONCLUSIONS

The reoperation of the MV in children with congenital MV diseases poses a formidable challenge, manifested by a high postoperative mortality rate and re-intervention rate. Patiently and meticulously repair based on the types of MV disease has demonstrated the capacity to enhance and sustain stable valve function and cardiac function in the vast majority of children. The use of the double-orifice MV technique did not achieve ideal therapeutic results in children with complex valve lesions.

摘要

背景

我们旨在研究先天性二尖瓣疾病患儿二尖瓣(MV)再次手术的结果,并总结我们的治疗经验。

方法

在这项单中心回顾性研究中,我们从2013年1月至2023年7月期间接受二尖瓣修复的265例患者中纳入了24例年龄小于18岁接受二尖瓣再次手术的患者。二尖瓣再次手术基于二尖瓣疾病的类型。采用Cox回归分析死亡和二次二尖瓣再次手术的危险因素。

结果

共有5例患者接受了二次二尖瓣再次手术。3例患者早期死亡,1例患者晚期死亡。整个队列的3年和5年生存率分别为86.6%±7.3%和72.1%±14.5%。在二尖瓣再次手术期间应用双孔二尖瓣技术的患者明显更倾向于接受机械二尖瓣置换(P<0.0001)。二尖瓣再次手术期间使用双孔二尖瓣技术被确定为二次二尖瓣再次手术的独立危险因素(HR=8.136,95%CI=1.099-60.240;P=0.040)。

结论

先天性二尖瓣疾病患儿的二尖瓣再次手术是一项艰巨的挑战,表现为术后高死亡率和再次干预率。根据二尖瓣疾病的类型进行耐心细致的修复已证明能够在绝大多数儿童中增强并维持稳定的瓣膜功能和心脏功能。双孔二尖瓣技术在复杂瓣膜病变患儿中未取得理想的治疗效果。

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