Nieto A, Mazón A, Caballero L, Gil M C
An Esp Pediatr. 1985 Apr 15;22(5):383-92.
This study compares the pharmacokinetics of two preparations of slow-release theophylline, one of them already known, and the other one a new product (micronized), very well accepted by pediatric patients. Two similar groups of fifteen patients each all of then asthmatic children under ten years of age, were selected and given a single oral dose of 10 mg/kg of one of the preparations. The pharmacokinetic parameters (T 1/2, Kel, VD, Cl and AUC) did not differ between both groups. The new product could further be used more safely, due to its lower incidence of "erratic" behaviour.
本研究比较了两种缓释茶碱制剂的药代动力学，其中一种已为人知，另一种是新产品（微粉化），很受儿科患者欢迎。选择了两组相似的患者，每组15名，均为10岁以下的哮喘儿童，给他们单次口服10mg/kg其中一种制剂。两组之间的药代动力学参数（T 1/2、Kel、VD、Cl和AUC）没有差异。由于新产品“不稳定”行为的发生率较低，因此可以更安全地使用。
