Lotner G Z, Vanderpool G E, Carroll S, Tinkelman D G, Spangler D L
Ann Allergy. 1983 Jan;50(1):27-9.
To facilitate administration of sustained-release theophylline in pediatric patients fourteen children with asthma were studied using intact capsules versus the granular contents in apple sauce. In a cross-over study during multiple dose intervals the effectiveness of this administration technique was demonstrated for maintaining bioavailability and sustained-release characteristics.
为便于给儿科患者使用缓释型茶碱，对14名哮喘患儿进行了研究，比较使用完整胶囊与将颗粒内容物混入苹果酱中的情况。在一项多剂量间隔的交叉研究中，证明了这种给药技术在维持生物利用度和缓释特性方面的有效性。
