Wolfe M M, Jain D K, Edgerton J R
Ann Intern Med. 1985 Aug;103(2):215-7. doi: 10.7326/0003-4819-103-2-215.
A 63-year-old man with a 2-year history of upper gastrointestinal ulcers was found to have the Zollinger-Ellison syndrome. Despite histologic verification of gastrinoma, several fasting serum gastrin concentrations were normal. However, in response to intravenous secretin infusion, a paradoxical increase in serum gastrin levels indicative of gastrinoma was seen. Although serum gastrin concentrations in patients with suspected gastrinoma may be persistently normal, provocative testing may be necessary to establish the diagnosis of the Zollinger-Ellison syndrome.
一名有2年上消化道溃疡病史的63岁男性被诊断为佐林格-埃利森综合征。尽管通过组织学检查证实为胃泌素瘤，但多次空腹血清胃泌素浓度均正常。然而，静脉注射促胰液素后，血清胃泌素水平出现反常升高，提示胃泌素瘤。虽然疑似胃泌素瘤患者的血清胃泌素浓度可能持续正常，但可能需要进行激发试验以确诊佐林格-埃利森综合征。
