Di Carlo Paola, Serra Nicola, Sergi Consolato Maria, Toia Francesca, Battaglia Emanuele, Fasciana Teresa Maria Assunta, Rodolico Vito, Giammanco Anna, Salamone Giuseppe, Cordova Adriana, Capuano Angela, Spatola Giovanni Francesco, Malta Ginevra, Cascio Antonio
Department of Health Promotion, Mother and Child Care, Internal Medicine and Medical Specialties, University of Palermo, 90127 Palermo, Italy.
Department of Neuroscience, Reproductive Sciences and Dentistry-Audiology Section, University of Naples Federico II, Via Pansini 5, 80131 Naples, Italy.
Antibiotics (Basel). 2025 Mar 9;14(3):283. doi: 10.3390/antibiotics14030283.
Bilio-pancreatic tumors are a severe form of cancer with a high rate of associated mortality. These patients showed the presence of bacteria such as and spp. in the bile-pancreatic tract. Therefore, efficient antibiotic therapy is essential to reduce bacterial resistance and adverse events in cancer patients. Recent studies on the seasonality of infectious diseases may aid in developing effective preventive measures. This study examines the seasonal impact on the bile microbiota composition and the antibiotic resistance of its microorganisms in patients with hepato-pancreatic-biliary cancer. We retrospectively evaluated the effect of the seasonally from 149 strains isolated by 90 Italian patients with a positive culture of bile samples collected through endoscopic retrograde cholangiopancreatography between 2010 and 2020. Across all seasons, the most frequently found bacteria were , spp., and spp. Regarding antibiotic resistance, bacteria showed the highest resistance to 3GC, fluoroquinolones, aminoglycosides, fosfomycin, and piperacillin-tazobactam in the summer and the lowest resistance in the spring, except for carbapenems and colistin. Antibiotic resistance has negative effects in cancer patients who rely on antibiotics to prevent and treat infections. Knowing whether bacterial and fungal resistance changes with the seasons is key information to define adequate and more effective antibiotic therapy.
胆胰肿瘤是一种严重的癌症形式，相关死亡率很高。这些患者的胆胰管中存在诸如 和 属等细菌。因此，有效的抗生素治疗对于降低癌症患者的细菌耐药性和不良事件至关重要。近期关于传染病季节性的研究可能有助于制定有效的预防措施。本研究考察了季节对肝胰胆管癌患者胆汁微生物群组成及其微生物抗生素耐药性的影响。我们回顾性评估了2010年至2020年间通过内镜逆行胰胆管造影收集的90例意大利胆汁样本培养阳性患者分离出的149株菌株的季节性影响。在所有季节中，最常发现的细菌是 、 属和 属。关于抗生素耐药性，除碳青霉烯类和黏菌素外，细菌在夏季对第三代头孢菌素（3GC）、氟喹诺酮类、氨基糖苷类、磷霉素和哌拉西林 - 他唑巴坦的耐药性最高，在春季最低。抗生素耐药性对依赖抗生素预防和治疗感染的癌症患者有负面影响。了解细菌和真菌耐药性是否随季节变化是确定适当且更有效抗生素治疗的关键信息。
