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新型分子特征可选择性预测结肠癌的临床结局。

Novel Molecular Signatures Selectively Predict Clinical Outcomes in Colon Cancer.

作者信息

Lahorewala Sarrah, Panda Chandramukhi S, Aguilar Karina, Morera Daley S, Zhu Huabin, Gramer Adriana L, Bhuiyan Tawhid, Nair Meera, Barrett Amanda, Bollag Roni J, Lokeshwar Vinata B

机构信息

Departments of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

Department of Pathology Medical College of Georgia, Augusta University, Augusta, GA 30912, USA.

出版信息

Cancers (Basel). 2025 Mar 7;17(6):919. doi: 10.3390/cancers17060919.

DOI:10.3390/cancers17060919
PMID:40149256
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11940726/
Abstract

Among the 152,810 estimated new cases of adenocarcinoma of the colon (COAD) and the rectum (READ) in 2024, the rates of colorectal cancer (CRC) are increasing in young adults (age < 55 years) [...].

摘要

在2024年估计的152,810例结肠癌(COAD)和直肠癌(READ)新发病例中,年轻成年人(年龄<55岁)的结直肠癌(CRC)发病率正在上升[...]。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/c1db3ed5358f/cancers-17-00919-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/9d0d18a5fea1/cancers-17-00919-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/cca4ab7e8f60/cancers-17-00919-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/bb786c0f9f9a/cancers-17-00919-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/984abc9daa7f/cancers-17-00919-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/c1db3ed5358f/cancers-17-00919-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/9d0d18a5fea1/cancers-17-00919-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/cca4ab7e8f60/cancers-17-00919-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/bb786c0f9f9a/cancers-17-00919-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/984abc9daa7f/cancers-17-00919-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/5f52/11940726/c1db3ed5358f/cancers-17-00919-g005.jpg

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本文引用的文献

1
Evaluation of the efficacy and safety of first- and second-line immunotherapy in patients with metastatic colorectal cancer: a systematic review and network meta-analysis based on randomized controlled trials.评估转移性结直肠癌患者一线和二线免疫治疗的疗效和安全性:基于随机对照试验的系统评价和网络荟萃分析。
Front Immunol. 2024 Sep 18;15:1439624. doi: 10.3389/fimmu.2024.1439624. eCollection 2024.
2
Cancer statistics, 2024.2024年癌症统计数据。
CA Cancer J Clin. 2024 Jan-Feb;74(1):12-49. doi: 10.3322/caac.21820. Epub 2024 Jan 17.
3
HYAL4-V1/Chondroitinase (Chase) Drives Gemcitabine Resistance and Predicts Chemotherapy Failure in Patients with Bladder Cancer.
HYAL4-V1/Chondroitinase (Chase) 驱动吉西他滨耐药并预测膀胱癌患者化疗失败。
Clin Cancer Res. 2021 Aug 1;27(15):4410-4421. doi: 10.1158/1078-0432.CCR-21-0422. Epub 2021 May 24.
4
Diagnosis and Treatment of Metastatic Colorectal Cancer: A Review.转移性结直肠癌的诊断与治疗:综述
JAMA. 2021 Feb 16;325(7):669-685. doi: 10.1001/jama.2021.0106.
5
Prediction of mortality in metastatic colorectal cancer in a real-life population: a multicenter explorative analysis.真实人群中转移性结直肠癌患者死亡的预测:一项多中心探索性分析。
BMC Cancer. 2020 Nov 25;20(1):1149. doi: 10.1186/s12885-020-07656-w.
6
Health Economic Models for Metastatic Colorectal Cancer: A Methodological Review.转移性结直肠癌的健康经济学模型:方法学综述。
Pharmacoeconomics. 2020 Jul;38(7):683-713. doi: 10.1007/s40273-020-00908-4.
7
A Novel Splice Variant of HYAL-4 Drives Malignant Transformation and Predicts Outcome in Patients with Bladder Cancer.一种新型 HYAL-4 剪接变体驱动膀胱癌恶性转化并预测患者预后。
Clin Cancer Res. 2020 Jul 1;26(13):3455-3467. doi: 10.1158/1078-0432.CCR-19-2912. Epub 2020 Feb 24.
8
A chemokine/chemokine receptor signature potentially predicts clinical outcome in colorectal cancer patients.趋化因子/趋化因子受体特征可能预测结直肠癌患者的临床结局。
Cancer Biomark. 2019;26(3):291-301. doi: 10.3233/CBM-190210.
9
Revisiting the hallmarks of cancer: The role of hyaluronan.重新审视癌症的特征:透明质酸的作用。
Semin Cancer Biol. 2020 May;62:9-19. doi: 10.1016/j.semcancer.2019.07.007. Epub 2019 Jul 15.
10
Matrix Hyaluronan-CD44 Interaction Activates MicroRNA and LncRNA Signaling Associated With Chemoresistance, Invasion, and Tumor Progression.基质透明质酸-CD44相互作用激活与化疗耐药、侵袭及肿瘤进展相关的微小RNA和长链非编码RNA信号通路。
Front Oncol. 2019 Jun 21;9:492. doi: 10.3389/fonc.2019.00492. eCollection 2019.