Leonard R J, Kiener D, Charpied G, Kelly A
Ann Otol Rhinol Laryngol. 1985 May-Jun;94(3):258-62.
Repeated stripping of the vocal folds in patients with recurrent vocal nodules may produce permanent, negative effects on voice quality. Hoarseness can be present with no evidence of structural or functional disease on indirect laryngoscopy. A common assumption is that scar tissue has formed, though the relationship between scarring and voice quality is not clear. In the study reported here, cats were subjected to four strippings of the left vocal fold at 6- to 8-week intervals. Tissues obtained were examined for changes in the composition of the mucosa and its nervous network. Alterations observed over the four strippings included 1) an increasing component of fibrous tissue and 2) apparent changes in both the number and structure of nervous elements. Implications of the findings for voice production, clinical management, and further research are discussed.
对复发性声带小结患者反复进行声带剥离可能会对嗓音质量产生永久性的负面影响。间接喉镜检查时，患者可能出现声音嘶哑，但无结构或功能疾病的证据。一种常见的假设是形成了瘢痕组织，尽管瘢痕形成与嗓音质量之间的关系尚不清楚。在本报告的研究中，猫每隔6至8周接受4次左侧声带剥离。对获取的组织进行检查，以观察黏膜及其神经网络组成的变化。在4次剥离过程中观察到的改变包括：1）纤维组织成分增加；2）神经元件的数量和结构均出现明显变化。文中讨论了这些发现对发声、临床管理及进一步研究的意义。
