Holtveg Thomas R, Reimer Jensen Anne Marie, Bock Ask, Suarez-Zdunek Moises Alberto, Knudsen Andreas D, Nordestgaard Børge G, Afzal Shoaib, Benfield Thomas, Ostrowski Sisse R, Biering-Sørensen Tor, Frikke-Schmidt Ruth, Nielsen Susanne D
Department of Infectious Diseases, Copenhagen University Hospital-Rigshospitalet, 2100 Copenhagen, Denmark.
Department of Cardiology, Copenhagen University Hospital-Herlev and Gentofte Herlev, 2730 Herlev, Denmark.
Biomolecules. 2025 Mar 11;15(3):401. doi: 10.3390/biom15030401.
People with HIV (PWH) have a high risk of peripheral artery disease (PAD), and high-sensitivity troponin (hsTnT) and NT-pro B-type natriuretic peptide (NT-proBNP) may be useful biomarkers for PAD in PWH. We assessed associations between hsTnT and NT-proBNP and both prevalent PAD and de novo PAD. Adult PWH were examined at baseline and after 2 years. Inclusion criteria were (1) measurements of hsTnT and NT-proBNP at baseline and (2) ankle brachial index (ABI) at baseline for prevalent PAD and both visits for de novo PAD. PAD was defined as ABI ≤ 0.9. We included 1011 PWH, and 88 (8.7%) had PAD at baseline. Among 802 PWH, 29 (3.6%) had de novo PAD at follow-up. A doubling in hsTnT concentration was associated with prevalent PAD with an OR 1.41 (95% CI: 1.02-1.96, = 0.04) and 1.40 (95% CI: 0.99-1.98, = 0.055) in a base model and an adjusted model, respectively. High hsTnT was associated with a risk ratio of 3.39 (95% CI: 1.24-9.27, = 0.02) for de novo PAD in an unadjusted model and 3.44 (95% CI: 0.98-12.10, = 0.05) after adjustments. NT-proBNP was not associated with PAD. Thus, hsTnT was associated with higher odds of prevalent PAD and increased risk of de novo PAD.
人类免疫缺陷病毒感染者（PWH）患外周动脉疾病（PAD）的风险很高，高敏肌钙蛋白（hsTnT）和N末端B型利钠肽原（NT-proBNP）可能是PWH中PAD的有用生物标志物。我们评估了hsTnT和NT-proBNP与现患PAD和新发PAD之间的关联。成年PWH在基线和2年后接受检查。纳入标准为：（1）基线时测量hsTnT和NT-proBNP；（2）现患PAD在基线时测量踝臂指数（ABI），新发PAD在两次就诊时均测量ABI。PAD定义为ABI≤0.9。我们纳入了1011例PWH，其中88例（8.7%）在基线时患有PAD。在802例PWH中，29例（3.6%）在随访时出现新发PAD。hsTnT浓度翻倍与现患PAD相关，在基础模型和调整模型中，比值比分别为1.41（95%CI：1.02-1.96，P = 0.04）和1.40（95%CI：0.99-1.98，P = 0.055）。在未调整模型中，高hsTnT与新发PAD的风险比为3.39（95%CI：1.24-9.27，P = 0.02），调整后为3.44（95%CI：0.98-12.10，P = 0.05）。NT-proBNP与PAD无关。因此，hsTnT与现患PAD的较高几率和新发PAD的风险增加相关。
