Morioka S, Ono M, Tanaka N, Orita K
Gan To Kagaku Ryoho. 1985 Jul;12(7):1470-5.
We studied the synergistic activation of rat alveolar macrophages (AM) by cepharanthine (Ceph.) and OK-432. Rat AM could be rendered much more tumoricidal against Walker-256 tumors in vitro after the i.v. injection of ceph. (5 mg/Kg) and OK-432 (5 KE/rat) thao of ceph. or OK-432 only. Radioactivity of 14C-acetate-OK-432 trapped in murine lung after the i.v. injection of mixed of ceph. was much higher than of 14C-acetate-OK-432 only. Rat AM could be rendered tumoricidal by incubation in vitro with OK-432, but not with ceph. This finding suggests that if OK-432 is injected intravenously with mixed of with ceph., of OK-432 is trapped much more up by the lung without mixture, therefore AM can be much more tumoricidal. Intravenous administration of OK-432 with ceph. may be useful for reduction of lung metastasis by tumoricidal AM.
我们研究了千金藤素（Ceph.）与OK-432对大鼠肺泡巨噬细胞（AM）的协同激活作用。静脉注射千金藤素（5mg/Kg）和OK-432（5KE/大鼠）后，大鼠AM在体外对Walker-256肿瘤的杀瘤能力比单独注射千金藤素或OK-432时更强。静脉注射千金藤素混合物后，小鼠肺中捕获的14C-醋酸盐-OK-432的放射性比单独注射14C-醋酸盐-OK-432时高得多。大鼠AM在体外与OK-432孵育可产生杀瘤能力，但与千金藤素孵育则无此作用。这一发现表明，如果将OK-432与千金藤素混合静脉注射，OK-432被肺捕获的量比不混合时多得多，因此AM的杀瘤能力更强。静脉注射OK-432与千金藤素混合物可能有助于通过具有杀瘤能力的AM减少肺转移。
