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脱氢丙氨酸酯的实用一锅法合成。

A practical one-pot synthesis of dehydroalanine esters.

作者信息

Shi Qingyuan, Zhu Mengxiao, Liang Zhenchu, Dong Xu, Zhang Minyue, Yang Lili, Sun Pingping, Xing Chuanyi, Zha Xiaohao, Li Fei, He Hongliang, Chen Dongyin

机构信息

Medical Basic Research Innovation Center for Cardiovascular and Cerebrovascular Diseases, Ministry of Education, International Joint Laboratory for Drug Target of Critical Illnesses, School of Pharmacy, Nanjing Medical University Nanjing 211166 China

Innovation Center of Suzhou Nanjing Medical University Suzhou 215000 China.

出版信息

RSC Adv. 2025 Mar 27;15(12):9359-9363. doi: 10.1039/d5ra00035a. eCollection 2025 Mar 21.

DOI:10.1039/d5ra00035a
PMID:40151529
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11947901/
Abstract

A practical one-pot synthesis of various dehydroalanine esters was realized a CsCO-mediated simultaneous esterification/elimination process, starting from commercially available N-protected serines and various haloalkanes. This protocol provided easy access to structurally diverse dehydroalanine-based building blocks, which were successfully applied to construct more complex dehydroalanine derived molecules.

摘要

通过碳酸铯介导的同时酯化/消除过程，从市售的N-保护丝氨酸和各种卤代烷出发，实现了各种脱氢丙氨酸酯的实用一锅法合成。该方案提供了一种简便的方法来获得结构多样的基于脱氢丙氨酸的构建块，这些构建块已成功应用于构建更复杂的脱氢丙氨酸衍生分子。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abff/11947901/561aa5235307/d5ra00035a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abff/11947901/2a2822bf9ae7/d5ra00035a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abff/11947901/561aa5235307/d5ra00035a-f2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abff/11947901/2a2822bf9ae7/d5ra00035a-f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abff/11947901/561aa5235307/d5ra00035a-f2.jpg

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