McCue J D
Arch Intern Med. 1985 Jul;145(7):1212-6.
From 1979 to 1982, the four years of this study, episodes of gram-negative bacillary bacteremia occurred in a 489-bed community teaching hospital--an increase of 15.9%. Mortality related to bacteremia was 19.4% overall and only 3.2% for the 158 episodes involving nonfatal underlying illnesses, lower figures than those reported in the past. The severity of underlying illnesses in bacteremic patients dominated all other clinical variables that were studied as prognostic factors for the outcome of the episode. The same bacteremia-related mortality was seen in patients who had empirically received (1) multiple-antibiotic regimens in which one or more drugs were active against the pathogenic organism(s), (2) either an appropriate aminoglycoside or beta-lactam antibiotic alone, or (3) both an aminoglycoside antibiotic and a beta-lactam antibiotic active against the pathogenic organism(s).
在本研究开展的1979年至1982年这四年间，一家拥有489张床位的社区教学医院发生了革兰氏阴性杆菌菌血症，发病率增长了15.9%。菌血症相关的总体死亡率为19.4%，在158例伴有非致命基础疾病的病例中，死亡率仅为3.2%，这一数字低于过去报道的水平。菌血症患者基础疾病的严重程度在所有其他作为该疾病预后因素进行研究的临床变量中占主导地位。在经验性接受以下治疗的患者中观察到相同的菌血症相关死亡率：（1）多种抗生素联合治疗方案，其中一种或多种药物对致病微生物有活性；（2）单独使用合适的氨基糖苷类抗生素或β-内酰胺类抗生素；（3）同时使用对致病微生物有活性的氨基糖苷类抗生素和β-内酰胺类抗生素。
