Ravid M, Lang R, Jutrin I
Arch Intern Med. 1985 Jul;145(7):1321-3.
The antihypertensive effect of four beta-blocking agents given once daily was compared with that of placebo in a prospective, crossover, double-blind study of 150 patients. The preparations tested were slow-release propranolol hydrochloride, 160 mg, atenolol, 100 mg, slow-release oxprenolol hydrochloride, 160 mg, and metoprolol, 200 mg. Propranolol and atenolol produced a significant decline in lying, standing, and postexercise blood pressure and pulse rate values. The effects of oxprenolol and metoprolol were not significantly different from that of placebo.
在一项针对150名患者的前瞻性、交叉、双盲研究中，比较了四种每日服用一次的β受体阻滞剂与安慰剂的降压效果。所测试的制剂为160毫克缓释盐酸普萘洛尔、100毫克阿替洛尔、160毫克缓释盐酸氧烯洛尔和200毫克美托洛尔。普萘洛尔和阿替洛尔使卧位、立位及运动后血压和脉搏率值显著下降。氧烯洛尔和美托洛尔的效果与安慰剂无显著差异。
