胸腺基质淋巴细胞生成素在系统性硬化症间质性肺疾病中的初步研究
Thymic stromal lymphopoietin in systemic sclerosis interstitial lung disease: a pilot study.
作者信息
Pellicano Chiara, Cusano Giuseppina, Colalillo Amalia, Villani Francesca, Carnazzo Valeria, Basile Umberto, De Filippis Francesca, Gigante Antonietta, Paone Gregorino, Rosato Edoardo
机构信息
Department of Translational and Precision Medicine, Sapienza University of Rome, Italy.
UOC of Clinical Pathology DEA II level, Hospital Santa Maria Goretti-ASL Latina, Italy.
出版信息
Clin Exp Rheumatol. 2025 Aug;43(8):1414-1421. doi: 10.55563/clinexprheumatol/s4m3ax. Epub 2025 Mar 20.
OBJECTIVES
Systemic sclerosis (SSc) is an autoimmune disease, characterised by microvascular alterations, dysregulation of immune system and fibrosis. The most important complication is interstitial lung disease (ILD). The aim of this study was to evaluate serum levels of thymic stromal lymphopoietin (TSLP) in SSc patients and healthy controls (HC). The secondary aim was to correlate TSLP with skin fibrosis and extension of ILD.
METHODS
75 SSc patients and 20 HC were enrolled and serum TSLP levels were measured in both cohorts. Pulmonary function tests (PFTs), high-resolution computed tomography (HRCT) and exhaled fraction of nitric oxide (FeNO) were assessed in SSc patients. A visual semi-quantitative staging system, tomographic fibrosis score (TFS), was used to assess SSc-ILD.
RESULTS
Serum levels of TSLP were higher in SSc patients than HC. A positive correlation between TSLP and mRSS was observed (r=0.409, p<0.001) and a negative correlation was found between TSLP and FVC (r=-0.356, p<0.01). Serum TSLP was significantly higher in SSc patients with Type 2 inflammation than patients without Type 2 inflammation [172 pg/ml (IQR 154.67;224.67) vs. 150 pg/ml (IQR 110;210.33), p<0.05]. The median value of serum TSLP was significantly higher in SSc patients with TFS ≥ 5% than SSc patients with TFS <5% [216.67 pg/ml (IQR 172;298.67) vs 140.67 pg/ml (IQR 122;166.67), p<0.001).
CONCLUSIONS
In conclusion, TSLP might have a key role in ILD and skin fibrosis.
目的
系统性硬化症（SSc）是一种自身免疫性疾病，其特征为微血管改变、免疫系统失调和纤维化。最重要的并发症是间质性肺疾病（ILD）。本研究的目的是评估系统性硬化症患者和健康对照者（HC）血清中胸腺基质淋巴细胞生成素（TSLP）的水平。次要目的是将TSLP与皮肤纤维化及ILD的范围相关联。
方法
纳入75例系统性硬化症患者和20例健康对照者，并测量两组人群的血清TSLP水平。对系统性硬化症患者进行肺功能测试（PFTs）、高分辨率计算机断层扫描（HRCT）和呼出一氧化氮分数（FeNO）评估。采用视觉半定量分期系统——断层扫描纤维化评分（TFS）来评估系统性硬化症相关ILD。
结果
系统性硬化症患者血清TSLP水平高于健康对照者。观察到TSLP与改良Rodnan皮肤评分（mRSS）呈正相关（r = 0.409，p < 0.001），且TSLP与用力肺活量（FVC）呈负相关（r = -0.356，p < 0.01）。2型炎症的系统性硬化症患者血清TSLP显著高于无2型炎症的患者[172 pg/ml（四分位间距154.67；224.67） vs. 150 pg/ml（四分位间距110；210.33），p < 0.05]。TFS≥5%的系统性硬化症患者血清TSLP的中位数显著高于TFS<5%的系统性硬化症患者[216.67 pg/ml（四分位间距172；298.67） vs 140.67 pg/ml（四分位间距122；166.67），p < 0.001]。
结论
总之，TSLP可能在ILD和皮肤纤维化中起关键作用。
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