Papanicolaou G, Nikas D, Ahn Y, Condos S, Fielding L P
Arch Surg. 1985 Aug;120(8):926-32. doi: 10.1001/archsurg.1985.01390320050010.
The effects of small-bowel obstruction on the regional distribution of blood flow and water content were studied in a new chronic dog model. Nonstrangulative obstruction was induced 40 cm proximal to the canine ileocolic valve. Blood flow was measured with 15-micron microspheres and hemodynamic and respiratory values were recorded before (experimental phase I) and five days after (experimental phase II) the induction of the obstruction. Two separate control groups of dogs were studied: baseline controls and sham-operative groups (phases I and II). Hemodynamic and respiratory values were stable in both phases in all groups. A comparison of sham phase-II data with the experimental phase-II data in the 120-cm segment of bowel proximal to the site of obstruction showed an 85% increase in blood flow (range, 49% to 106%); for the 280 cm of bowel proximal to the site of obstruction, there was a 6% increase in water content (range, 5% to 9%), and a 39% decrease in dry bowel weight (range, 34% to 46%). These findings help illustrate the pathophysiologic characteristics of microvascular changes in bowel obstruction, which are likely to have particular clinical significance for patients with cardiopulmonary diseases.
在一种新的慢性犬模型中研究了小肠梗阻对局部血流分布和含水量的影响。在犬回盲瓣近端40厘米处诱发非绞窄性梗阻。用15微米微球测量血流，并在梗阻诱发前（实验阶段I）和诱发后五天（实验阶段II）记录血流动力学和呼吸值。研究了两组单独的犬对照组：基线对照组和假手术组（阶段I和II）。所有组在两个阶段的血流动力学和呼吸值均稳定。将假手术阶段II的数据与梗阻部位近端120厘米肠段的实验阶段II数据进行比较，结果显示血流增加了85%（范围为49%至106%）；在梗阻部位近端280厘米的肠段，含水量增加了6%（范围为5%至9%），肠干重减少了39%（范围为34%至46%）。这些发现有助于阐明肠梗阻时微血管变化的病理生理特征，这可能对心肺疾病患者具有特殊的临床意义。
