对INO80型染色质重塑因子的机制性见解。
Mechanistic insights into INO80-type chromatin remodelers.
作者信息
Bowman Gregory D
机构信息
TC Jenkins Department of Biophysics, Johns Hopkins University, Baltimore MD, 21218, USA.
出版信息
Curr Opin Struct Biol. 2025 Jun;92:103030. doi: 10.1016/j.sbi.2025.103030. Epub 2025 Mar 27.
Abstract
Chromatin remodelers are adenosine triphosphate (ATP)-driven enzymes that physically reorganize nucleosomes, the basic packaging unit of all eukaryotic chromosomes. INO80, SWR1/SRCAP, and TIP60 are large multisubunit remodelers that share similar components yet have distinct biochemical and biological functions. This review summarizes key architectural features of these complexes and how they engage DNA, nucleosomes, and hexasomes to carry out their tasks.
摘要
染色质重塑因子是由三磷酸腺苷（ATP）驱动的酶，可对核小体进行物理重组，核小体是所有真核染色体的基本包装单位。INO80、SWR1/SRCAP和TIP60是大型多亚基重塑因子，它们具有相似的组成成分，但具有不同的生化和生物学功能。本综述总结了这些复合物的关键结构特征，以及它们如何与DNA、核小体和六聚体相互作用以执行其任务。
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