Saha Anjanabha, Wittmeyer Jacqueline, Cairns Bradley R
Department of Oncological Sciences and Howard Hughes Medical Institute, Huntsman Cancer Institute, University of Utah School of Medicine, 2000 Circle of Hope, Salt Lake City, UT 84112, USA.
Results Probl Cell Differ. 2006;41:127-48. doi: 10.1007/400_005.
Chromatin remodeling complexes (remodelers) are a set of diverse multi-protein machines that reposition and restructure nucleosomes. Remodelers are specialized, containing unique proteins that assist in targeting, interaction with modified nucleosomes, and performing specific chromatin tasks. However, all remodelers contain an ATPase domain that is highly similar to known DNA translocases/helicases, suggesting that DNA translocation is a property common to all remodelers. Here we examine the different reactions they perform in vitro, focusing on the SWI/SNF and the ISWI complexes, and explore how DNA translocation might be utilized to execute various remodeling processes.
染色质重塑复合体（重塑因子）是一组多样的多蛋白机器，可重新定位和重组核小体。重塑因子具有特异性，包含独特的蛋白质，这些蛋白质有助于靶向定位、与修饰的核小体相互作用以及执行特定的染色质任务。然而，所有重塑因子都含有一个与已知DNA转位酶/解旋酶高度相似的ATP酶结构域，这表明DNA转位是所有重塑因子共有的特性。在这里，我们研究它们在体外进行的不同反应，重点关注SWI/SNF和ISWI复合体，并探讨DNA转位如何被用于执行各种重塑过程。
