Schneider H, Streicher E
Artif Organs. 1985 May;9(2):180-3. doi: 10.1111/j.1525-1594.1985.tb04371.x.
A new polysulfone capillary membrane has been tested ex vivo for its clearance performance under diffusive, combined diffusive and convective, and pure convective solute mass transfer. As was expected, increasing convective mass transfer produced augmentation only of clearances of high molecular weight solutes, and to a much lesser extent than reported for other membranes. This behavior is explainable by the enormous diffusive clearance capacity of the new membrane, which nearly reaches its theoretical maximal value, as derived from a computer model. Based on the very high hydraulic permeability, which makes this membrane equally suitable for filtrative and diffusive procedures, no membrane solute retention was found up to a molecular weight of 5,000 daltons. Stable hemocompatibility parameters (leukocytes, thrombocyte, and complement measurements) demonstrated absence of activation by this membrane during treatment. It is concluded that since its clearance performance is near the theoretical maximal and it shows superior biocompatibility, the membrane exhibits negligible interaction with the transported solutes independent of the transport mode.
一种新型聚砜毛细管膜已在体外进行了测试，以考察其在扩散、扩散与对流相结合以及纯对流溶质传质条件下的清除性能。正如预期的那样，增加对流传质仅能提高高分子量溶质的清除率，且提高程度远低于其他膜的报道。这种行为可以通过新膜巨大的扩散清除能力来解释，该能力几乎达到了从计算机模型推导得出的理论最大值。基于非常高的水力渗透率，这使得该膜同样适用于过滤和扩散过程，在分子量达到5000道尔顿之前未发现膜对溶质的保留现象。稳定的血液相容性参数（白细胞、血小板和补体测量）表明该膜在治疗过程中未激活。结论是，由于其清除性能接近理论最大值且表现出卓越的生物相容性，该膜与被转运溶质的相互作用可忽略不计，且与转运模式无关。
